The purpose of Abernethy and colleagues' study was to see whether the compendia provided “comprehensive, research-based, and timely information for off-label prescribing in oncology.” They found that the compendia listed widely differing numbers of off-label uses; only 1 compendium listed each off-label indication covered by the reviewers' own 2006 systematic review of 14 off-label indications. Only 2 indications were listed by all compendia. The centerpiece of the study is an evaluation of how thoroughly the compendia cited the published evidence. For each indication, the reviewers compared the number of articles cited by a compendium with the number that they found in their own systematic review. The compendia cited different articles for the same off-label indication, and their supporting materials cited far fewer articles than the reviewers' 2006 systematic review. Of 43 articles identified by the reviewers' systematic review, the compendia cited 0 to 7. The reviewers' 2008 re-review of gemcitabine found another 25 reports; the 2008 version of the compendia added few or none of these citations. In short, the compendia were inconsistent, incomplete, and out-of-date. Abernethy and colleagues' findings speak for themselves in making the case for change.