Letters
7 July 2009

Do Methodological Flaws Invalidate a Randomized Trial of Lifestyle Modification Programs in Obese Patients?

Publication: Annals of Internal Medicine
Volume 151, Number 1
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References

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Rosenberger WFSverdlov O. Handling covariates in the design of clinical trials. Stat Sci. 2008;23:404-19.
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Pi-Sunyer FXAronne LJHeshmati HMDevin JRosenstock JRIO-North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA. 2006;295:761-75. [PMID: 16478899]
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Gadbury GLCoffey CSAllison DB. Modern statistical methods for handling missing repeated measurements in obesity trial data: beyond LOCF. Obes Rev. 2003;4:175-84. [PMID: 12916818]
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Mallinckrodt CHLane PWSchnell DPeng YMancuso JP. Recommendations for the primary analysis of continuous endpoints in longitudinal clinical trials. Drug Inf J. 2008;42:303-19.

Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 151Number 17 July 2009
Pages: 70 - 71

History

Published online: 7 July 2009
Published in issue: 7 July 2009

Keywords

Authors

Affiliations

James P. Mancuso, PhD
From Pfizer, New London, CT 06320; and Pfizer, Inc., South Lyme, CT 06376.
Robert A. Gerber, PharmD, MA, MBA
From Pfizer, New London, CT 06320; and Pfizer, Inc., South Lyme, CT 06376.
Andres G. Digenio, MD, PhD
From Pfizer, New London, CT 06320; and Pfizer, Inc., South Lyme, CT 06376.
Disclosures: None disclosed.

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James P. Mancuso, Robert A. Gerber, Andres G. Digenio. Do Methodological Flaws Invalidate a Randomized Trial of Lifestyle Modification Programs in Obese Patients?. Ann Intern Med.2009;151:70-71. [Epub 7 July 2009]. doi:10.7326/0003-4819-151-1-200907070-00015

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