The 2008 IOM committee recommended establishing a national program “with authority, overarching responsibility, sustained resources, and adequate capacity to ensure production of credible, unbiased information about what is known and what is not known about clinical effectiveness” (2). The current committee expanded this recommendation by calling upon the secretary of the Department of Health and Human Services “to establish a mechanism—such as a coordinating advisory body—with the authority to strategize, organize, monitor, evaluate, and report on the implementation and impact of the CER Program.” The committee recognized that many agencies of the federal government are engaged in research that fits some or all of the key elements of CER. To make the best use of the funds allocated for CER, these agencies should be jointly accountable for spending CER funds on research that reflects the same conceptualization of CER. Therefore, these disparate efforts should use a single definition of CER and the same definitions of outcomes and measures of function and illness. This form of cross-agency coordination is compatible with each agency focusing on the form of research with which it has the greatest experience.