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Identification of Osteoporosis Risk Genes: The Tip of the Iceberg

Joseph M. Zmuda, PhD
[+] Article, Author, and Disclosure Information

From Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261.

Grant Support: Dr. Zmuda was supported, in part, by grant R01-AR051124 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Potential Conflicts of Interest: None disclosed.

Requests for Single Reprints: Joseph M. Zmuda, PhD, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261; e-mail, zmudaj@edc.pitt.edu.

Ann Intern Med. 2009;151(8):581-582. doi:10.7326/0003-4819-151-8-200910200-00013
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Osteoporosis is a complex, multifactorial skeletal disorder that afflicts an estimated 5 to 8 million Americans aged 50 years or older, and another 21 to 40 million may be at increased risk for it (1). In the United States, about 1.5 million fractures annually are attributable to osteoporosis (2). These fractures cause long-lasting disability and dependence, and few individuals fully return to prefracture levels of activity (3). The societal burden of osteoporosis is expected to increase substantially in the next 50 years because of changes in demography and improvements in life expectancy (4). These trends are likely to occur not only in the United States but throughout the world, making elucidation of the causes of osteoporosis an urgent priority.



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