The research pipeline may always be more porous for individuals with substantial personal commitments. It may take them longer to achieve academic success and their publication count may be more modest (13). But their experience and maturity may greatly enhance the quality of their science. They may be uniquely suited to leading large, multidisciplinary teams to discoveries at the intersection of traditional disciplines. These leaders will stay in research only if they can avoid a Faustian dilemma between scientific achievement and personal responsibility. They require the means of covering small crises at home and at work, flexible hours, protected time, a quiet office, freedom to fail, and open-minded mentors and collaborators. If we are to benefit from senior scientists who have invested in their personal lives, the research enterprise (funders, universities, mentors, and colleagues) must work with current junior clinical scientists to lay new, more flexible pipeline to scientific discovery and academic tenure.