Mechanical interventions to reduce venous stasis without increasing bleeding risk are an appealing method of thromboprophylaxis after stroke (3). These interventions include graduated compression stockings, which reduce the pooling of blood in the deep veins by applying greater pressure at the ankle than higher up the leg, and intermittent pneumatic compression devices, which cyclically inflate and deflate to promote venous return. Of these options, graduated compression stockings have the advantages of being less expensive and easier to use, and they also permit greater patient mobility. On the basis of evidence of their efficacy in patients who have had surgery (4), as well as a single small study (5) that suggests they are effective in patients with stroke, physicians often include graduated compression stockings in the acute care of patients after stroke (3, 6). However, 2 large randomized trials (2, 7), including CLOTS (Clots in Legs Or sTockings after Stroke) Trial 2 in this issue (7), prompt a reevaluation of the role of graduated compression stockings for preventing venous thromboembolism in patients with acute stroke and, by extension, in other populations.