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Dihydrotestosterone: Hormone or Autocrine–Paracrine Signal?

Ronald S. Swerdloff, MD; and Christina Wang, MD
[+] Article, Author, and Disclosure Information

From Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502, and David Geffen School of Medicine at University of California, Los Angeles, CA 90509.

Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-2335.

Requests for Single Reprints: Ronald S. Swerdloff, MD, Harbor–University of California, Los Angeles, Medical Center, 1124 West Carson Street, Torrance, CA 90502.

Current Author Addresses: Dr. Swerdloff: Harbor–University of California, Los Angeles, Medical Center, 1124 West Carson Street, Torrance, CA 90502.

Dr. Wang: Harbor–University of California, Los Angeles, Medical Center, General Clinical Research Center, 1000 West Carson Street, Torrance, CA 90509.

Ann Intern Med. 2010;153(10):678-679. doi:10.7326/0003-4819-153-10-201011160-00013
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In this issue, Idan and colleagues report a randomized trial that examined the long-term effects of DHT treatment on prostate growth in healthy, middle-aged men without prostate disease. The editorialists discuss the study's contribution to our understanding of androgen pharmacology and insights into androgen biology in multiple target organs. They conclude that DHT acts as a hormone in tissues without high concentrations of 5α-reductase enzymes but acts mainly in an autocrine–paracrine manner in such tissues as the prostate, where 5α-reductase is abundant.

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