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Standard-Dose Tegafur Combined With Uracil Is Not Safe Treatment After Severe Toxicity From 5-Fluorouracil or Capecitabine

Maarten J. Deenen, PharmD; Wim E. Terpstra, MD, PhD; Annemieke Cats, MD, PhD; Henk Boot, MD, PhD; and Jan H.M. Schellens, MD, PhD
[+] Article, Author, and Disclosure Information

From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands; Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands; and The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.

Potential Conflicts of Interest: None disclosed.

Ann Intern Med. 2010;153(11):767-768. doi:10.7326/0003-4819-153-11-201012070-00023
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Leukocyte counts and thrombocyte counts in the peripheral blood after capecitabine plus oxaliplatin and bevacizumab therapy and after UFT plus leucovorin therapy.

Arrows indicate the start and end of diarrhea. Time is measured in days after the start of chemotherapy, which is day 0. UFT = tegafur–uracil.

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