Summaries for Patients |

Tuberous Sclerosis Complex in Adult Women FREE

[+] Article, Author, and Disclosure Information

The full report is titled “Recognition of Tuberous Sclerosis in Adult Women: Delayed Presentation With Life-Threatening Consequences.” It is in the 21 June 2011 issue of Annals of Internal Medicine (volume 154, pages 806-813). The authors are D. Seibert, C.H. Hong, F. Takeuchi, C. Olsen, O. Hathaway, J. Moss, and T.N. Darling.

Ann Intern Med. 2011;154(12):I-48. doi:10.7326/0003-4819-154-12-201106210-00004
Text Size: A A A

What is the problem and what is known about it so far?

Tuberous sclerosis complex (TSC) is caused by tumors that grow in multiple organs. It is often recognized in children who develop characteristic skin lesions, seizures, and cognitive deficiencies. How the disease manifests in adults is less understood.

Why did the researchers do this particular study?

To understand the presentation and manifestations of TSC in adult patients.

Who was studied?

79 women who enrolled in an observational study at the National Institutes of Health.

How was the study done?

A careful history and physical examination were performed, along with x-rays and measurements of lung function.

What did the researchers find?

Approximately two thirds of the women with TSC reported problems during childhood that were consistent with the disease but were not recognized at the time. In the remaining women, some features of TSC may have been present earlier in life but were not sufficient to make a diagnosis. Life-threatening problems occurred in some women with TSC, including tumors that damaged the lungs or kidneys.

What were the limitations of the study?

Full medical records during childhood were not available to confirm what abnormalities were present or recognized. The women in this study may have had fewer or milder neurologic problems (such as seizures) but more severe problems in other organs (such as the lungs or kidneys) than did other patients with TSC.

What are the implications of the study?

Tuberous sclerosis complex may not be recognized or may cause problems until adulthood in some patients. Delays in recognizing the problem may delay therapy.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.