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Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis

Serena Guiducci, MD; Mirko Manetti, PhD; and Marco Matucci-Cerinic, MD, PhD
[+] Article and Author Information

From University of Florence, 50139 Florence, Italy.


Potential Conflicts of Interest: None disclosed.


Ann Intern Med. 2011;155(1):65-66. doi:10.7326/0003-4819-155-1-201107050-00014
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MSC in systemic sclerosis
Posted on July 20, 2011
Sabino Guillermo Echebarria Mendieta
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Conflict of Interest: None Declared

The concept of vascular lesion in Systemic Sclerosis , well-known in recent studies , may be defined as basal ( laminae and endothelial cells damage , with subsequent intima enlargement , luminal stenosis and vessel occlusion ( chronic ischemia ). The subsequent stages are defined as endothelial apoptosis , pericytes activation and intima proliferation , with vessel occlusion , capillary rete decrease and microaneurysms -onset.

Additional features are vascular regulation alteration , with neoangiogenesis decrease ( TGF _ beta ) . The role of pathogenic mechanisms in these descriptions are : Ab-mediated immune lesion , and ischemia / oxidative stress . The role of collagenase type IV ( granzyme ) secreted by activated T cells ( direct cytotoxic action in endothelial and basal membrane ) is described. ( Basu D et al.Anti-Scl 70 . Autoimmunity 2005 ; 38: 65-72 ). MSC transplantation and PBSC , MSC function would be related to CD 133+ , CD 34 + , KDR + and CD 45 + in acute cardiovascular events and endothelial differentiation in subacute phase.

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