The full content of Annals is available to subscribers

Subscribe/Learn More  >
In the Clinic |


E. Michael Lewiecki, MD
Ann Intern Med. 2011;155(1):ITC1-1. doi:10.7326/0003-4819-155-1-201107050-01001
Text Size: A A A

Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to an increased risk for fracture (1). Bone strength is determined by properties that include bone mineral density (BMD), bone geometry (size and shape of bone), degree of mineralization, microarchitecture, and bone turnover. It is a common disease with serious clinical consequences. In the United States, about 44 million people have osteoporosis or osteopenia (low bone mass) that could lead to low-trauma fractures. About 50% of white women and 20% of men will have an osteoporosis-related fracture in their lifetimes. Fractures of the hip and spine may be disabling and are associated with mortality rates that are about 20% greater than that of an age-matched population. A fragility fracture (i.e., a nontraumatic fracture or one that occurs with low trauma, such as a fall from the standing position) of any type is a sentinel event that increases the risk for future fractures. To reduce the burden of osteoporotic fractures, high-risk patients must be identified, evaluated for factors contributing to skeletal fragility, and treated to reduce fracture risk. Pharmacologic agents can reduce the risk for fracture in appropriately selected patients, with a generally favorable safety profile.

First Page Preview

View Large
First page PDF preview





CME Activities are only available to ACP members and Individual Annals subscribers. If you are a member or a subscriber please sign in. Otherwise please become a member or subscribe to Annals.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.