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15 December 1994 | Volume 121 Issue 12 | Pages 953-959
The complexities of the chronic fatigue syndrome and the methodologic problems associated with its study indicate the need for a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses.We propose a conceptual framework and a set of guidelines that provide such an approach. Our guidelines include recommendations for the clinical evaluation of fatigued persons, a revised case definition of the chronic fatigue syndrome, and a strategy for subgrouping fatigued persons in formal investigations.
*For a listing of members of the Study Group, see Appendix.
Author and Article Information
From the Centers for Disease Control and Prevention, Atlanta, Georgia; the National Institutes of Health, Bethesda, Maryland; Prince Henry Hospital and University of New South Wales, Sydney, Australia; University of Oxford and Warneford Hospital, Oxford, United Kingdom; and Brigham and Women's Hospital and Harvard University, Boston, Massachusetts.
DIAGNOSIS AND TREATMENT
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
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Requests for Reprints: Keiji Fukuda, MD, MPH, Mailstop A15, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.
Acknowledgments: The authors thank Carla Arpino, Judy Basso, Lyria Boast, Janet K. Dale, Karen Ezrine, Marya Grambs, K. Kimberly Kenney, Teruo Kitani, David Klonoff, Dorothy Knight, Gerhard R.F. Krueger, Hirohiko Kuratsune, Gudrun Lindh, Lars Lindquist, Lisa Livens, Alison Mawle, David McCluskey, John O'Connor, Orvalene Prewitt, Bonnie Randall, Karen B. Schmaling, Scott Schmid, John Stewart, Lars Wahlstrom, Denis Wakefield, and Andrew Wilson.
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R Salamon, C Verret, M A Jutand, M Begassat, F Laoudj, F Conso, and P Brochard Health consequences of the first Persian Gulf War on French troops Int. J. Epidemiol., April 1, 2006; 35(2): 479 - 487. [Abstract] [Full Text] [PDF] |
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J. Cornuz, I. Guessous, and B. Favrat Fatigue: a practical approach to diagnosis in primary care. Can. Med. Assoc. J., March 14, 2006; 174(6): 765 - 767. [Full Text] [PDF] |
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T. Takahashi, F. Yu, S.-j. Zhu, J. Moriya, H. Sumino, S. Morimoto, N. Yamaguchi, and T. Kanda Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome. Evid. Based Complement. Altern. Med., March 1, 2006; 3(1): 109 - 115. [Abstract] [Full Text] [PDF] |
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C. Ryall, D. Coggon, R. Peveler, I. Reading, and K. T. Palmer A case-control study of risk factors for arm pain presenting to primary care services Occup. Med., March 1, 2006; 56(2): 137 - 143. [Abstract] [Full Text] [PDF] |
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K Pardaens, L Haagdorens, P Van Wambeke, A Van den Broeck, and B Van Houdenhove How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study Clinical Rehabilitation, January 1, 2006; 20(1): 56 - 66. [Abstract] [PDF] |
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A. Sankey, C. M. Hill, J. Brown, L. Quinn, and A. Fletcher A Follow-up Study of Chronic Fatigue Syndrome in Children and Adolescents: Symptom Persistence and School Absenteeism Clinical Child Psychology and Psychiatry, January 1, 2006; 11(1): 126 - 138. [Abstract] [PDF] |
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D. C. Randall, F. H. Cafferty, J. M. Shneerson, I. E. Smith, M. B. Llewelyn, and S. E. File Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome J Psychopharmacol, November 1, 2005; 19(6): 647 - 660. [Abstract] [PDF] |
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