Table of Contents

August 17, 1999; 131 (4)

Articles

  • Educational methods that encourage physicians to adopt practice guidelines are needed. This study found that a multifaceted education strategy can improve neurologists' adherence to practice recommendations endorsed by specialty societies.

  • Thorough screening of patients with a family history of pancreatic cancer is feasible. Clinical data combined with imaging studies can be used to identify high-risk patients who have dysplasia. The role of molecular genetic testing is uncertain at this time.

  • In patients with hemophilia and late-stage HIV disease, viral load predicts disease progression independently of CD4 cell counts. Because viral load most strongly predicts progression immediately after it is measured, it seems to reflect the current level of immunosuppression.

Brief Communications

  • Many women in a managed care organization who accepted a prescription for hormone replacement therapy identified counseling needs that are not included in widely used hormone replacement therapy guidelines.

  • Enhanced infection-control strategies reduced transmission of vancomycin-resistant enterococci in an oncology unit in which these organisms were endemic.

Review

  • This review examines the goals of antihyperglycemic therapy and the mechanisms of action, efficacy, nonglycemic benefits, cost, and safety profile of each of the five approved classes of oral agents. A rationale for the use of these agents as monotherapy, in combination with each other, and in combination with insulin is also provided.

Editorial

  • In this issue, Gifford and colleagues report on an intervention designed to improve adherence to practice guidelines. Despite the study's many strengths, the intervention's effects on physician behavior were not impressive. What factors may explain these findings, and what other methods can be used to change physician behavior?

On Being a Doctor

  • What world would I join—full-time physicianhood or health care administration? Did I go through medical school, residency, and fellowship to be a cop? Or is it better to be a cop than a copee?

Letters

Medical Writings: Book Notes

Currents

Ad Libitum

Book Listings

Medical Notices

Updates from the Annual Session

  • Infectious diseases continues to be one of the fastest-changing fields of clinical medicine. The topics covered in this Update include emergence of antibiotic-resistant organisms, the continuing problems with food-borne disease, and the potential role of certain bacterial infections in coronary heart disease and acute myocardial infarction.