Table of Contents

January 2, 2001; 134 (1)

Articles

  • Long-Term Weight Loss and Changes in Blood Pressure: Results of the Trials of Hypertension Prevention, Phase II

    • Victor J. Stevens,
    • Eva Obarzanek,
    • Nancy R. Cook,
    • I-Min Lee,
    • Lawrence J. Appel,
    • Delia Smith West,
    • N. Carole Milas,
    • Mildred Mattfeldt-Beman,
    • Lorna Belden,
    • Charlotte Bragg,
    • Marian Millstone,
    • James Raczynski,
    • Amy Brewer,
    • Bali Singh,
    • Jerome Cohen,
    • and for the Trials of Hypertension Prevention Research Group
    Ann Intern Med January 2, 2001 134:1-11

    Even modest weight loss can lead to clinically significant long-term reductions in blood pressure and reduced risk for hypertension.

  • Cardiorespiratory Fitness and the Progression of Carotid Atherosclerosis in Middle-Aged Men

    • Timo A. Lakka,
    • Jari A. Laukkanen,
    • Rainer Rauramaa,
    • Riitta Salonen,
    • Hanna-Maaria Lakka,
    • George A. Kaplan,
    • and Jukka T. Salonen
    Ann Intern Med January 2, 2001 134:12-20

    Good cardiorespiratory fitness is associated with slower progression of early atherosclerosis in middle-aged men. These findings are important because they emphasize that middle-aged men can be evaluated for cardiorespiratory fitness to estimate their future risk for atherosclerotic vascular diseases.

  • Relation between Directly Detected Patent Foramen Ovale and Ischemic Brain Lesions in Sport Divers

    • Markus Schwerzmann,
    • Christian Seiler,
    • Ernst Lipp,
    • Raphael Guzman,
    • Karl O. Lövblad,
    • Martin Kraus,
    • and Nils Kucher
    Ann Intern Med January 2, 2001 134:21-24

    In divers, the significance of a patent foramen ovale and its potential relation to paradoxical gas emboli remain uncertain. This study found that regardless of whether a diver has a patent foramen ovale, diving is associated with ischemic brain lesions.

Brief Communications

  • Diagnosis of Primary HIV-1 Infection

    • Eric S. Daar,
    • Susan Little,
    • Jacqui Pitt,
    • Joanne Santangelo,
    • Pauline Ho,
    • Nina Harawa,
    • Peter Kerndt,
    • Janis V. Giorgi,
    • Jiexin Bai,
    • Paula Gaut,
    • Douglas D. Richman,
    • Susan Mandel,
    • Stephen Nichols,
    • and for the Los Angeles County Primary HIV Infection Recruitment Network*
    Ann Intern Med January 2, 2001 134:25-29

    No sign or symptom was found to allow targeted screening for primary HIV infection. Although assays for HIV RNA are more sensitive than those for p24 antigen in diagnosing primary infection, they are more expensive and are more likely to yield false-positive results.

Academia and Clinic

  • Reforming the Core Clerkship in Internal Medicine: The SGIM/CDIM Project

    • Allan H. Goroll,
    • Gail Morrison,
    • Eric B. Bass,
    • Robert Jablonover,
    • Dionne Blackman,
    • Roger Platt,
    • Alison Whelan,
    • and Francine P. Hekelman
    Ann Intern Med January 2, 2001 134:30-37

    The Society of General Internal Medicine and the Clerkship Directors in Internal Medicine constructed a new curriculum for the internal medicine core clerkship. This reform effort has led to a new consensus on the structure and content of the core clerkship in internal medicine, one that refocuses attention on learning basic generalist competencies and moves a substantial proportion of training into the outpatient setting.

Review

  • Nonhypoglycemic Effects of Thiazolidinediones

    • Akhil A. Parulkar,
    • Merri L. Pendergrass,
    • Ramona Granda-Ayala,
    • Tri Richard Lee,
    • and Vivian A. Fonseca
    Ann Intern Med January 2, 2001 134:61-71

    The authors discuss the nonhypoglycemic effects of the thiazolidinediones, with an emphasis on the potential of these drugs to improve other components of the insulin resistance syndrome, such as dyslipidemia, hypertension, and impaired fibrinolysis. They also describe the thiazolidinediones' effects in other insulin-resistant states, such as the polycystic ovary syndrome; examine their effects on body weight and composition; and draw attention to other potential effects currently being investigated.

Editorials

  • Obesity and Hypertension: What Should We Do?

    • Thomas G. Pickering
    Ann Intern Med January 2, 2001 134:72-74

    As highlighted in Stevens and colleagues' article in this issue, there is no simple solution to the problem of obesity. Dealing with it will require action at several levels: policy, education (of both the public and heath care providers), and incorporation of a team approach to patient care that involves dietitians and health educators.

  • Diagnosis of Acute HIV Infection: It's Time To Get Moving!

    • Timothy Flanigan and
    • Karen T. Tashima
    Ann Intern Med January 2, 2001 134:75-77

    The article by Daar and colleagues in this issue is an important contribution regarding appropriate testing for acute or “primary” HIV infection. Primary care physicians should immediately begin to integrate routine screening for HIV infection so that individual patients and communities may benefit as soon as possible.

  • Authors, Editors, and Readers in the Brave New (Electronic) World

    • Frank Davidoff
    Ann Intern Med January 2, 2001 134:78

    Electronic journals may or may not replace print versions in the lives of readers, but electronic systems have already proven invaluable in moving information back and forth, tracking it, retrieving it, and helping to do all the other intricate editorial housekeeping that's essential in creating a journal—not bad for a technology that's really just getting started.

Letters

  • Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction

    • Roger Peverill
    Ann Intern Med January 2, 2001 134:80

  • Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction

    • H. Joan Waitkevicz and
    • Deborah Axelrod
    Ann Intern Med January 2, 2001 134:80-81

  • Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction

    • Mark R. Goldstein
    Ann Intern Med January 2, 2001 134:81

  • Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction

    • Deborah Grady and
    • Eric Vittinghoff
    Ann Intern Med January 2, 2001 134:81

  • Sex Differences in HIV-1 Viral Load Due to Sex Difference in CCR5 Expression

    • Pierre Portales,
    • Jacques Clot,
    • and Pierre Corbeau
    Ann Intern Med January 2, 2001 134:81-82

Medical Writings

  • Narrative Medicine: Form, Function, and Ethics

    • Rita Charon
    Ann Intern Med January 2, 2001 134:83-87

    Narrative medicine is medicine practiced with the narrative competence to recognize, interpret, and be moved to action by the predicaments of others. Examining medicine's practice of narrative writing may help us to understand its significance, its consequences, and the means to participate in it responsibly.

Medical Writings: Book Notes

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

Updates from the Annual Session

  • Update in Hematology

    • Geraldine P. Schechter,
    • Harish P.G. Dave,
    • and Barbara M. Alving
    Ann Intern Med January 2, 2001 134:38-46

    The hematology topics that generated the most attention in the past year were the newer concepts in anticoagulation, thrombosis, hemostasis, transfusion therapy, hemochromatosis, and novel therapies for hematologic malignancy.

  • Psychopharmacologic Treatment Strategies for Depression, Bipolar Disorder, and Schizophrenia

    • Ira D. Glick,
    • Trisha Suppes,
    • Charles DeBattista,
    • Rona J. Hu,
    • and Stephen Marder
    Ann Intern Med January 2, 2001 134:47-60

    This paper presents an updated synopsis for three major psychiatric illnesses: major depression, bipolar disorder, and schizophrenia. Current definitions, updated diagnostic criteria, short- and long-term treatment strategies with algorithms, and special challenges for the clinician are discussed for each of these illnesses.

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This Issue

January 2, 2001; 134 (1)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Editorials
  6. Letters
  7. Medical Writings
  8. Medical Writings: Book Notes
  9. Ad Libitum
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients
  13. Updates from the Annual Session

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