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Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk
TO THE EDITOR:
Paynter and colleagues (1) showed that the widely replicated 9p21 genetic risk factor affected risk in the Women's Genome Health Study, largely independent of traditional risk factors. They were able to reliably measure this genetic marker years after patient recruitment because DNA is invariant, in contrast to such biomarkers as C-reactive protein (CRP). The power to detect improvement in cardiovascular event prediction by adding a new risk factor to traditional risk factors depends on the total number of events in the study. The Women's Genome Health Study recruited women of mean age 52 years who had low risk for incident cardiovascular disease: a 2.1% event …
