Table of Contents

June 16, 2009; 150 (12)

Articles

  • Effects of Calcium Supplementation on Body Weight and Adiposity in Overweight and Obese Adults: A Randomized Trial

    • Jack A. Yanovski,
    • Shamik J. Parikh,
    • Lisa B. Yanoff,
    • Blakeley I. Denkinger,
    • Karim A. Calis,
    • James C. Reynolds,
    • Nancy G. Sebring,
    • and Teresa McHugh
    Ann Intern Med June 16, 2009 150:821-829; doi:10.1059/0003-4819-150-12-200906160-00005

    Some data suggest that body weight is inversely associated with calcium intake. Yanovski and colleagues tested whether supplemental calcium might prevent weight gain among 340 overweight and obese patients randomly assigned to receive supplemental calcium, 1500 mg/d, or placebo. They found no differences in body weight, body mass index, or body fat mass between the groups after 2 years. They conclude that calcium supplementation is unlikely to prevent weight gain in persons who are overweight or obese.

  • Red Yeast Rice for Dyslipidemia in Statin-Intolerant Patients: A Randomized Trial

    • David J. Becker,
    • Ram Y. Gordon,
    • Steven C. Halbert,
    • Benjamin French,
    • Patti B. Morris,
    • and Daniel J. Rader
    Ann Intern Med June 16, 2009 150:830-839; doi:10.1059/0003-4819-150-12-200906160-00006

    Red yeast rice is a dietary supplement that can decrease low-density lipoprotein (LDL) cholesterol levels and could be a treatment option for patients with statin-associated myopathy. Investigators randomly assigned 62 patients with dyslipidemia and a history of intolerance to at least 1 statin to receive red yeast rice, 1800 mg twice daily, or placebo. After 12 and 24 weeks, LDL and total cholesterol levels improved more in the red yeast rice group than in the placebo group. Pain, creatinine phosphokinase, and liver enzyme levels did not differ between the groups.

  • Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function: A Randomized Trial

    • Liesbeth Bax,
    • Arend-Jan J. Woittiez,
    • Hans J. Kouwenberg,
    • Willem P.T.M. Mali,
    • Erik Buskens,
    • Frederik J.A. Beek,
    • Branko Braam,
    • Frans T.M. Huysmans,
    • Leo J. Schultze Kool,
    • Matthieu J.C.M. Rutten,
    • Cornelius J. Doorenbos,
    • Johannes C.N.M. Aarts,
    • Ton J. Rabelink,
    • Pierre-François Plouin,
    • Alain Raynaud,
    • Gert A. van Montfrans,
    • Jim A. Reekers,
    • Anton H. van den Meiracker,
    • Peter M.T. Pattynama,
    • Peter J.G. van de Ven,
    • Dammis Vroegindeweij,
    • Abraham A. Kroon,
    • Michiel W. de Haan,
    • Cornelis T. Postma,
    • and Jaap J. Beutler
    Ann Intern Med June 16, 2009 150:840-848; doi:10.1059/0003-4819-150-12-200906160-00119

    Renal stents are commonly used to treat atherosclerotic renal artery stenosis (ARAS). In this randomized trial, Bax and coworkers compared medical treatment of ARAS (anti-hypertensive treatment, a statin, and aspirin) with medical treatment plus stenting among 140 patients with ARAS and impaired renal function. Patients who underwent stenting had no clear benefits, and several complications occurred, including 2 procedure-related deaths.

  • Adverse Events After Outpatient Colonoscopy in the Medicare Population

    • Joan L. Warren,
    • Carrie N. Klabunde,
    • Angela B. Mariotto,
    • Angela Meekins,
    • Marie Topor,
    • Martin L. Brown,
    • and David F. Ransohoff
    Ann Intern Med June 16, 2009 150:849-857; doi:10.1059/0003-4819-150-12-200906160-00008

    Complication rates of colonoscopy in older patients are not well established. Warren and colleagues measured 30-day cardiac and gastrointestinal event rates in a random sample of 53 220 Medicare beneficiaries who had outpatient colonoscopy and in a matched set of beneficiaries who did not. Rates of adverse events following colonoscopy were low, but increased with advancing age. They were also increased in patients who had polypectomy and in patients with comorbid conditions, such as diabetes, atrial fibrillation, congestive heart failure, or chronic obstructive lung disease.

Review

  • Narrative Review: Statin-Related Myopathy

    • Tisha R. Joy and
    • Robert A. Hegele
    Ann Intern Med June 16, 2009 150:858-868; doi:10.1059/0003-4819-150-12-200906160-00009

    Statin-related myopathy is a clinically important cause of statin intolerance and discontinuation. In this overview, Joy and Hegele cover the pathophysiology, epidemiology, clinical features, and management of statin-related myopathy. They discuss options for managing statin myopathy, including statin switching, nondaily dosing regimens, nonstatin alternatives, and coenzyme Q10 supplementation.

Perspectives

  • Catheter-Associated Urinary Tract Infection and the Medicare Rule Changes

    • Sanjay Saint,
    • Jennifer A. Meddings,
    • David Calfee,
    • Christine P. Kowalski,
    • and Sarah L. Krein
    Ann Intern Med June 16, 2009 150:877-884; doi:10.1059/0003-4819-150-12-200906160-00013

    Catheter-associated urinary tract infection, a common and potentially preventable complication of hospitalization, is a hospital-acquired complication chosen by the Centers for Medicare&Medicaid Services (CMS) for which hospitals no longer receive additional payment. Saint and colleagues examine the preventability of catheter-associated infection; review the CMS rule changes regarding the complication; assess the possible consequences of these changes; and provide guidance for hospital-based administrators, policymakers, epidemiologists, and clinicians.

Clinical Guidelines

  • Screening for Hepatitis B Virus Infection in Pregnancy: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement

    • U.S. Preventive Services Task Force
    Ann Intern Med June 16, 2009 150:869-873; doi:10.1059/0003-4819-150-12-200906160-00011

    The U.S. Preventive Services Task Force (USPSTF) reaffirms its 2004 recommendation on screening for hepatitis B virus (HBV) infection in pregnancy. The net benefit of screening remains well established. Clinicians should screen for HBV infection in pregnant women at their first prenatal visit (grade A recommendation).

  • Screening for Hepatitis B Virus Infection in Pregnant Women: Evidence for the U.S. Preventive Services Task Force Reaffirmation Recommendation Statement

    • Kenneth Lin and
    • John Vickery
    Ann Intern Med June 16, 2009 150:874-876; doi:10.1059/0003-4819-150-12-200906160-00012

    To support the USPSTF reaffirmation recommendation statement in this issue, the authors searched for large, high-quality studies published since the 2004 USPSTF recommendation on the benefits and harms of screening for HBV infection in pregnant women. They found no new evidence on the benefits or harms of screening for HBV infection in pregnant women. Previously published randomized trials support the 2004 USPSTF recommendation for screening.

Editorial

  • Balancing Randomized Trials With Anecdote

    • Paul S. Phillips
    Ann Intern Med June 16, 2009 150:885-886; doi:10.1059/0003-4819-150-12-200906160-00014

    Two articles in this issue apply the best available methodologies to statin myopathy. Joy and Hegele's systematic review of statin myopathy emphasizes findings from randomized, controlled trials. Becker and colleagues' randomized, controlled trial suggests that red yeast rice, a nutraceutical form of statin, may be safe for patients who cannot tolerate statins. Both articles give priority to controlled trials and deemphasize anecdote.

On Being a Doctor

  • Fault

    • Gordon D. Rubenfeld
    Ann Intern Med June 16, 2009 150:887-888; doi:10.1059/0003-4819-150-12-200906160-00015

    Crude tattoos of “LOVE” and “HATE” unfurled as the angry, muscular man clenched and unclenched his fists. Behind him at least 12 other family members, or perhaps gang members, who glared at me. To make matters worse, someone had called hospital security—add 2 beefy guys to a room that now felt very small.

Letters

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • Allan R. Glass
    Ann Intern Med June 16, 2009 150:889; doi:10.1059/0003-4819-150-12-200906160-00016

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • John Hansen-Flaschen
    Ann Intern Med June 16, 2009 150:889; doi:10.1059/0003-4819-150-12-200906160-00017

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • Mark D. Siegel
    Ann Intern Med June 16, 2009 150:889-890; doi:10.1059/0003-4819-150-12-200906160-00018

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • Tia Powell,
    • Guthrie Birkhead,
    • and Kelly Christ
    Ann Intern Med June 16, 2009 150:890; doi:10.1059/0003-4819-150-12-200906160-00019

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • Michael D. Christian,
    • Christian E. Sandrock,
    • Asha Devereaux,
    • James Geiling,
    • Dennis E. Amundson,
    • and Lewis Rubinson
    Ann Intern Med June 16, 2009 150:890-891; doi:10.1059/0003-4819-150-12-200906160-00020

  • Ethical Issues and the Allocation of Scarce Resources During a Public Health Emergency

    • Douglas B. White,
    • Bernard Lo,
    • and Mitch Katz
    Ann Intern Med June 16, 2009 150:891-892; doi:10.1059/0003-4819-150-12-200906160-00021

Ad Libitum

  • Feeling Death

    • C. Scott Williams
    Ann Intern Med June 16, 2009 150:868; doi:10.1059/0003-4819-150-12-200906160-00010

Medical Notices

  • Medical Notices

    Ann Intern Med June 16, 2009 150:0; doi:10.1059/0003-4819-150-12-200906160-00022

Summaries for Patients

  • Can Calcium Pills Help People Lose Weight?

    Ann Intern Med June 16, 2009 150:I-24; doi:10.1059/0003-4819-150-12-200906160-00001

  • Red Yeast Rice to Treat Cholesterol Problems in Patients Who Cannot Tolerate Statin Therapy Because of Muscle Pain

    Ann Intern Med June 16, 2009 150:I-28; doi:10.1059/0003-4819-150-12-200906160-00002

  • Adverse Events After Colonoscopy in the Medicare Population

    Ann Intern Med June 16, 2009 150:I-32; doi:10.1059/0003-4819-150-12-200906160-00004

  • Screening Pregnant Women for Hepatitis B Virus Infection: U.S. Preventive Services Task Force Recommendation

    Ann Intern Med June 16, 2009 150:I-36; doi:10.1059/0003-4819-150-12-200906160-00003

ACP Journal Club

  • Editorial: “Pragmatic” clinical trials: from whose perspective?

    Ann Intern Med June 16, 2009 150:JC6-2; doi:10.1059/0003-4819-150-12-200906160-02002

  • Annual screening for prostate cancer did not reduce mortality from prostate cancer

    Ann Intern Med June 16, 2009 150:JC6-4; doi:10.1059/0003-4819-150-12-200906160-02004

  • Periodic screening with prostate-specific antigen testing reduced mortality from prostate cancer

    Ann Intern Med June 16, 2009 150:JC6-5; doi:10.1059/0003-4819-150-12-200906160-02005

  • Adding radiotherapy to endocrine therapy improved survival in locally advanced prostate cancer

    Ann Intern Med June 16, 2009 150:JC6-6; doi:10.1059/0003-4819-150-12-200906160-02006

  • Review: Immediate routine lumbar-spine imaging does not improve clinical outcomes in low-back pain

    Ann Intern Med June 16, 2009 150:JC6-7; doi:10.1059/0003-4819-150-12-200906160-02007

  • Continued use of antipsychotic drugs increased long-term mortality in patients with Alzheimer disease

    Ann Intern Med June 16, 2009 150:JC6-8; doi:10.1059/0003-4819-150-12-200906160-02008

  • Oral vitamin K did not reduce bleeding in patients with excessive anticoagulation after receiving warfarin

    Ann Intern Med June 16, 2009 150:JC6-9; doi:10.1059/0003-4819-150-12-200906160-02009

  • Prasugrel prevented ischemic events compared with clopidogrel in patients having PCI for STEMI

    Ann Intern Med June 16, 2009 150:JC6-10; doi:10.1059/0003-4819-150-12-200906160-02010

  • Risk for breast cancer declined after postmenopausal hormone therapy was stopped

    Ann Intern Med June 16, 2009 150:JC6-11; doi:10.1059/0003-4819-150-12-200906160-02011

  • Use of nonsteroidal antiinflammatory drugs was associated with increased risks for death and hospitalization for MI and HF

    Ann Intern Med June 16, 2009 150:JC6-12; doi:10.1059/0003-4819-150-12-200906160-02012

  • Review: SSRIs are associated with increased risk for attempted or completed suicide in adolescents but not in adults or the elderly

    Ann Intern Med June 16, 2009 150:JC6-13; doi:10.1059/0003-4819-150-12-200906160-02013

  • Care coordination for patients with chronic conditions did not reduce hospitalizations or Medicare costs

    Ann Intern Med June 16, 2009 150:JC6-14; doi:10.1059/0003-4819-150-12-200906160-02014

  • Postmenopausal hormone therapy was cost-effective when started at age 50 years but not at 65 years

    Ann Intern Med June 16, 2009 150:JC6-15; doi:10.1059/0003-4819-150-12-200906160-02015

  • Glossary

    Ann Intern Med June 16, 2009 150:JC6-16; doi:10.1059/0003-4819-150-12-200906160-02016
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This Issue

June 16, 2009; 150 (12)
  1. Articles
  2. Review
  3. Perspectives
  4. Clinical Guidelines
  5. Editorial
  6. On Being a Doctor
  7. Letters
  8. Ad Libitum
  9. Medical Notices
  10. Summaries for Patients
  11. ACP Journal Club

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