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Rejuvenation in Older Adults Receiving Oral Ghrelin
- Ralf M. Nass, MD;
- Mary Lee Vance, MD; and
- Michael O. Thorner, MBBS, DSc
- From University of Virginia Health System, Charlottesville, VA 22908.
IN RESPONSE:
We appreciate the thoughtful comments in response to our article and offer some clarifications.
We believe that aging is not a disease but a complex multisystem decline that occurs over decades. It is likely that MK-677 acts at multiple sites, including the hypothalamus, the pituitary, and the periphery. We have no evidence that atherosclerosis impairs its action.
We did not perform other cancer screening in these healthy older adults. Women were carefully monitored with Papanicolaou smears and mammography, and prostate-specific antigen was monitored in men. …
