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Clinical guidelines recommend advice on appropriate footwear as part of the management of knee osteoarthritis. Shoes that reduce harmful knee loads are commercially available, but their effects are uncertain. This randomized trial compared the efficacy of unloading shoes versus conventional walking shoes in improving symptoms among patients with knee osteoarthritis.
Using a large nationwide database linked to a unique Staphylococcus aureus registry in Denmark, investigators studied whether having a first-degree relative with a prior admission for S aureus bacteremia is associated with an increased risk for the disease, independent of comorbid conditions or direct contamination.
Despite improvements in risk factors and reductions in diabetes complications in the United States, large gaps exist in achievement of these goals globally, particularly in low- and middle-income countries. This trial examined the effect of a multicomponent quality improvement strategy on improving cardiometabolic profiles in patients with diabetes seen in resource-constrained clinics in India and Pakistan
The best treatment options for binge-eating disorder are unclear. This systematic review summarizes trial evidence on the benefits and harms of various treatments for this disorder, including cognitive behavioral therapy, lisdexamfetamine, and second-generation antidepressants.
Pharmaceutical companies and other trial sponsors must submit certain trial results to ClinicalTrials.gov, but their validity is unclear. This article evaluates the validity of results posted on ClinicalTrials.gov for 100 industryfunded randomized trials that were used to support new drug approvals in the United States.
Bayesian adaptive clinical trial designs may be more efficient processes with lower sample sizes and shorter trial durations than traditional designs. This virtual execution of a large comparative effectiveness trial demonstrates the mechanics and feasibility of these designs.
On 2 March 2016, the National Academies of Science, Engineering, and Medicine released a congressionally mandated report on the state of research on ovarian cancer and its subtypes. This commentary summarizes findings and recommendations of key relevance to internists.
Hearing loss affects about 30 million persons in the United States. The National Academies of Sciences, Engineering, and Medicine recently released a report on hearing health care for adults. This commentary summarizes findings and recommendations from that report that are particularly relevant for physicians.
Hinman and colleagues report a randomized trial that compared shoes designed to unload the knee versus new conventional shoes. The editorialists discuss whether readily available, new, supportive lace-up shoes should be the current evidence-based recommendation for appropriate footwear while we wait for studies of knee biomechanics that might identify more effective interventions.
The review by Brownley and colleagues summarizes the evidence on treatment for binge-eating disorder, including approaches developed since binge eating was first recognized as a clinical disorder. The editorialist notes that the article raises some fundamental questions: What are we to make of this “new” diagnosis? Why has it come to light now? How should we approach our patients?
The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.