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Options are needed when initial therapy fails for hepatitis C virus (HCV) infection. In a phase 2 trial, sofosbuvir plus velpatasvir resulted in high rates of sustained viral response at 12 weeks in treatment-experienced patients with genotype 1 or 3 HCV infection.
Pangenotypic treatments for HCV infection would be useful worldwide. In a phase 2 trial, treatment with sofosbuvir plus velpatasvir resulted in high sustained virologic response at 12 weeks in patients infected with HCV genotypes 1 to 6.
Whether measures of central obesity, such as waist-to-hip ratio (WHR), provide additional information beyond body mass index (BMI) in defining mortality risks is unclear. This study examined data from a large cohort to compare the total and cardiovascular mortality risks for different combinations of BMI and WHR categories.
This meta-analysis of 35 prospective controlled studies evaluates the effectiveness of behavioral programs for patients with type 1 diabetes and explores factors that might moderate effectiveness.
This network meta-analysis of 132 randomized trials identifies important components and characteristics of successful behavioral programs for adults with type 2 diabetes.
This recommendation statement from the U.S. Preventive Services Task Force screening for abnormal blood glucose and type 2 diabetes mellitus in adults.
This position paper provides recommendations from the American College of Physicians addressing the expansion of retail health clinics while underscoring patient safety, communication, and collaboration among retail health clinics, physicians, and patients.
Provisions of the Affordable Care Act (ACA) help to reign in overuse within Medicare and the private markets. The author argues that the ACA is relatively silent on price control in the private market and provisions that tend to promote the consolidation of providers and reduce competition may command higher prices.
This commentary highlights “superbug infections” from agents transmitted by specialized endoscopes used for endoscopic retrograde cholangiopancreatography and the efforts under way to better understand the problem, develop creative solutions, and ensure patient safety.
Black box warnings have been the subject of controversy, due in part to their opaque connection to the underlying body of evidence. This commentary proposes a new structure for presenting black box warnings that takes into consideration the fundamental principles of evidence-based medicine.
Some older adults have difficulty managing their finances and are vulnerable to financial exploitation. Some have dementia, but others are cognitively intact. This commentary addresses whether we should assign these older adults to a specific condition.
Nurse practitioners and physicians are the topic of this issue's discussion from the Annals archive.
In this issue, Sahakyan and colleagues examine data from a large cohort and compare the total and cardiovascular mortality risks for various combinations of BMI and WHR categories. The editorialist reviews their results and asserts that clinicians must look beyond BMI when assessing adiposity to better determine persons at greater risk for cardiovascular disease.
Following admission of data fabrication by the first author in a similar study of ramipril for patients with peripheral arterial disease, Baker IDI Heart and Diabetes Institute conducted an independent investigation of the trial, published in Annals in 2006. Based on that investigation and the authors' analysis, the undersigned authors wish to retract this article due to an inability to adequately validate primary data sources.
The summary for patients based on an article that has been retracted is also being retracted.
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.