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This U.S. Preventive Services Task Force (USPSTF) update recommends biennial screening mammography for women aged 50 to 74 years (grade B recommendation). The USPSTF recommends against routine screening mammography in women aged 40 to 49 years (grade C recommendation) and against clinicians teaching women how to perform breast self-examination (grade D recommendation). Finally, the USPSTF found that evidence is insufficient to assess screening mammography in women aged 75 years or older, clinical breast examination beyond screening mammography in women aged 40 years or older, and either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities (I statements).