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Andrew S. Levey, MD; Juan P. Bosch, MD; Julia Breyer Lewis, MD; Tom Greene, PhD; Nancy Rogers, MS; David Roth, MD, for the Modification of Diet in Renal Disease Study Group*

The serum creatinine concentration is widely used as an index of renal function, but this measure is affected by factors other than the glomerular filtration rate (GFR). This study examined an equation to predict GFR from serum creatinine concentrations and other factors.

Topics: glomerular filtration rate, creatinine tests, serum, creatinine clearance, kidney diseases
  
Sapna Syngal, MD, MPH; Eugenie H. Coakley, MA, MPH; Walter C. Willett, MD, DrPH; Tim Byers, MD, MPH; David F. Williamson, PhD, MS; and Graham A. Colditz, MD, DrPH

Weight cycling was highly prevalent in a large cohort of middle-aged women. Independent of attained relative body weight, the risk for cholecystectomy associated with weight cycling was substantial.

Topics: cholecystectomy, women, weight reduction
  
Larry W. Moreland, MD; Michael H. Schiff, MD; Scott W. Baumgartner, MD; Elizabeth A. Tindall, MD; Roy M. Fleischmann, MD; Ken J. Bulpitt, MD; Arthur L. Weaver, MD; Edward C. Keystone, MD; Daniel E. Furst, MD; Philip J. Mease, MD; Eric M. Ruderman, MD; David A. Horwitz, MD; Daniel G. Arkfeld, MD; Leslie Garrison, MD, MPH; Daniel J. Burge, MD; Consuelo M. Blosch, MD; Mary L.M. Lange, MS; Neil D. McDonnell, PharmD; and Michael E. Weinblatt, MD

Etanercept can safely provide rapid, clinically significant, and sustained benefit in patients with active rheumatoid arthritis.

Topics: rheumatoid arthritis, etanercept
  
Kerstin Malmstrom, PhD; Guillermo Rodriguez-Gomez, MD; Jeremias Guerra, MD; Cesar Villaran, MD; Andres Piñeiro, MD; Lynn X. Wei, PhD; Beth C. Seidenberg, MD; Theodore F. Reiss, MD, for the Montelukast/Beclomethasone Study Group*

Beclomethasone had a larger mean effect than montelukast, but both drugs provided clinical benefit to patients with chronic asthma. This finding is consistent with the use of these agents as controller medications for chronic asthma.

Topics: asthma, beclomethasone, montelukast, asthma, chronic
  
Ronald D. Chervin, MD, MS; Daniel L. Murman, MD, MS; Beth A. Malow, MD, MS; and Vicken Totten, MD, MS

The cost–utility of polysomnography instead of home study or no testing for the diagnosis of the obstructive sleep apnea syndrome compares favorably with that of other procedures for which society judges the added utility per dollar spent to be worthwhile.

Topics: obstructive sleep apnea, polysomnography, sleep apnea syndromes, continuous positive airway pressure
  
Marius M. Hoeper, MD; Jost Niedermeyer, MD; Frank Hoffmeyer, MD; Peer Flemming, MD; and Helmut Fabel, MD

Patients who have had splenectomy may be at increased risk for pulmonary hypertension.

Topics: pulmonary hypertension, splenectomy
  
Roy M. Gulick, MD, MPH; Vincent McAuliffe, MD; Jeanne Holden-Wiltse, MPH; Clyde Crumpacker, MD; Leonard Liebes, PhD; Daniel S. Stein, MD; Patricia Meehan, PhD; Sheila Hussey, RN; Janet Forcht, RN; Fred T. Valentine, MD, for the AIDS Clinical Trials Group 150 and 258 Protocol Teams

Hypericin, the active compound in St. John's wort, caused significant phototoxicity and had no antiretroviral activity in HIV-infected patients.

Topics: hiv, acquired immunodeficiency syndrome, toxic effect, anti-retroviral agents, phototoxicity
  
Amy C. Justice, MD, PhD; Kenneth E. Covinsky, MD, MPH; and Jesse A. Berlin, ScD

This paper describes an approach for evaluating prognostic systems based on the accuracy and generalizability of the system's predictions.

Topics: colorectal cancer, calibration, external validity, mortality, colon cancer, rectal carcinoma
  
Lewis J. Smith, MD

In patients with asthma, the overall response rate to the gold standard treatment, corticosteroids, may be as low as 70%. Clearly, there is a need to identify treatments that are effective when corticosteroids are not. Malmstrom and colleagues' study in this issue contributes to other studies that have increased our understanding of the beneficial effects and safety of leukotriene receptor antagonists.

Topics: asthma
  
Allan I. Pack, MB, ChB, PhD; and Indira Gurubhagavatula, MD, MPH

In this issue, Chervin and colleagues present a cost–utility analysis that evaluates the relative effectiveness of three diagnostic strategies for the obstructive sleep apnea syndrome. This analysis points the way to a more rigorous cost-based approach to assessment of the relative value of different diagnostic strategies.

Topics: obstructive sleep apnea, economics
  
Catharine Dewar, PhD, MD, FRCPC
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Catharine Dewar, PhD, MD, FRCPC
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D. Gray Heppner Jr., MD; Robert A. Gasser Jr., MD; and Kent E. Kester, MD
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Jaime Soto, MD; and Jonathan Berman, MD, PhD
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Jean-Luc Cracowski, MD; Michel Mallaret, MD; and Gérald Vanzetto, MD, PhD
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Pietro Maffei, MD; Nicola Sicolo, MD; and Mario Plebani, MD
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Paolo Simioni, MD, PhD; Paolo Prandoni, MD, PhD; and Antonio Girolami, MD
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Topics: disease transmission, needle device, syringes, intravenous drug user, hiv, disease prevention, infection, ...
  
David A. Lacher, MD; and Matthew W. Morgan, MD, FRCPC
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Virginia Gennis, MD, MPH
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James D. Lewis, MD, MSCE; and David A. Asch, MD, MBA

Low reimbursement may limit the adoption of screening flexible sigmoidoscopy with or without biopsy in primary care practices.

Topics: reimbursement mechanisms, sigmoidoscopy, flexible fiberoptic sigmoidoscopy, medical coding, biopsy, medicare
  
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