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Isao Saito, MD, PhD; Aaron R. Folsom, MD; Frederick L. Brancati, MD; Bruce B. Duncan, MD, PhD; Lloyd E. Chambless, PhD; and Paul G. McGovern, PhD

In this study, predictors of coronary heart disease among patients with diabetes were levels of albumin, fibrinogen, and von Willebrand factor; factor VIII activity; and leukocyte count.

Topics: atherosclerosis, diabetes mellitus, type 2, coronary heart disease, coronary heart disease risk, ...
Robert Ross, PhD; Damon Dagnone, MSc; Peter J.H. Jones, PhD; Heidi Smith, BSc, RD; Anne Paddags, MSc; Robert Hudson, MD, PhD; and Ian Janssen, MSc

Weight loss induced by increased daily physical activity without caloric restriction substantially reduced obesity (particularly abdominal obesity) and insulin resistance in men. Exercise without weight loss reduced abdominal fat and prevented further weight gain.

Topics: obesity, weight reduction, diet, exercise, glucose
Roberta B. Ness, MD, MPH; Flora Ukoli, MD; Susan Hunt, MD; Sharon C. Kiely, MD; Melissa A. McNeil, MD; Vanessa Richardson, MD; Nancy Weissbach, MD; and Steven H. Belle, PhD

In this survey study, salaries significantly differed between male and female internists overall and in various medical practice settings.

Topics: salary and wages
Gemma Sesmilo, MD; Beverly M.K. Biller, MD; Joan Llevadot, MD, PhD; Douglas Hayden, MA; Greta Hanson, BS; Nader Rifai, PhD; and Anne Klibanski, MD

Long-term growth hormone replacement in men reduced levels of inflammatory cardiovascular risk markers, decreased central fat, and increased lipoprotein(a) and glucose levels without affecting lipid levels.

Topics: cardiovascular disease risk factors, somatotropin, somatotropin deficiency, somatropin, insulin-like growth factor i, ...
Karen L. Margolis, MD, MPH; Kristine E. Ensrud, MD, MPH; Pamela J. Schreiner, PhD; Holly K. Tabor, PhD, Study of Osteoporotic Fractures Research Group*

Total body weight was found to be useful in the prediction of hip, pelvis, and rib fractures when bone mineral density had not been measured.

Topics: fracture, elderly

Among the drug therapies used for the irritable bowel syndrome, smooth-muscle relaxants are beneficial when abdominal pain is the predominant symptom. The efficacy of bulking agents has not been established. Loperamide is effective for diarrhea, and data on psychotropic agents are inconclusive. Evidence for 5-hydroxytryptamine–receptor antagonists seems favorable.

Topics: irritable bowel syndrome

An understanding of the determinants of antibiotic consumption is critical to explain current patterns of use and to devise programs for reducing inappropriate use.

Topics: antibiotics

The author explores the idea that caring about health care costs can be brought to the bedside in a way that will sustain trust among patients and the public.

Topics: advocacy, patient advocacy

The study by Saito and colleagues in this issue highlights the importance of several nontraditional risk factors in the pathogenesis of increased cardiovascular disease associated with diabetes.

Topics: diabetes mellitus, diabetes mellitus, type 2, coronary heart disease risk
Elizabeth S. Klings, MD; and Harrison W. Farber, MD
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Israel Steiner, MD; Peter Farcas, MD; and Itzhak Wirguin, MD
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Anthony D. Harris, MD, MPH; Matthew H. Samore, MD; and Yehuda Carmeli, MD, MSc
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Topics: cancer, maps
Topics: diabetes mellitus, type 2, coronary heart disease risk
Topics: obesity, weight reduction, diet, exercise
Topics: salary and wages
Topics: cardiovascular disease risk factors, somatotropin, somatropin
Topics: fracture, elderly
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