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Ananda S. Prasad, MD, PhD; James T. Fitzgerald, PhD; Bin Bao, MD, PhD; Frances W.J. Beck, PhD; and Pranatharthi H. Chandrasekar, MD

Use of zinc lozenges was associated with reduced duration and severity of cold symptoms, especially cough. Improvement in clinical symptoms with zinc treatment may be related to a decrease in proinflammatory cytokine levels; in this study, however, the observed changes in cytokine levels did not significantly differ between zinc and placebo groups.

Topics: cytokine, common cold, plasma, zinc acetate, zinc, double-blind method
  

The waiting period for elective procedures, such as coronary artery bypass grafting, may be used to enhance in-hospital and early-phase recovery, improving patients' functional abilities and quality of life while reducing their hospital stay.

Topics: coronary artery bypass surgery, length of stay
  
Elif Arioglu, MD; Jennifer Duncan-Morin, RN; Nancy Sebring, RD; Kristina I. Rother, MD; Nicole Gottlieb, BA; Jay Lieberman, BS; David Herion, MD; David E. Kleiner, MD, PhD; James Reynolds, MD; Ahalya Premkumar, MD; Anne E. Sumner, MD; Jay Hoofnagle, MD; Marc L. Reitman, MD, PhD; and Simeon I. Taylor, MD, PhD

Troglitazone therapy improved metabolic control and increased body fat in patients with lipoatrophic diabetes. The substantial benefits of troglitazone must be balanced against the risk for hepatotoxicity, which can occur relatively late in the treatment course.

Topics: lipodystrophy, troglitazone
  
Voravit Ratanatharathorn, MD; Erik Carson, MD; Christopher Reynolds, MD; Lois J. Ayash, MD; John Levine, MD; Gregory Yanik, MD; Samuel M. Silver, MD, PhD; James L.M. Ferrara, MD; and Joseph P. Uberti, MD, PhD

The efficacy of rituximab for immune-mediated thrombocytopenia in the patient described here suggests that this drug may have activity in other autoimmune diseases or chronic graft-versus-host disease.

Topics: monoclonal antibodies, cd20 antigens, chimera organism, thrombocytopenia, graft-versus-host disease, chronic
  
Paulo F. Barroso, MD, PhD; Mauro Schechter, MD, PhD; Phalguni Gupta, PhD; Maria F. Melo, BS; Marcello Vieira, MD; Fernanda C. Murta, RN; Yeda Souza; and Lee H. Harrison, MD

Antiretroviral therapy reduces shedding of HIV in semen; in turn, this reduction probably decreases HIV transmissibility. However, a substantial proportion of patients may still be infectious and may harbor drug-resistant strains of the virus.

Topics: hiv, seminal fluid, anti-retroviral agents, viral load result
  

Given the progressive aging of the U.S. population, it may seem natural for geriatrics to become a separate specialty with its own academic department. The author recommends an alternative—a center on aging or pan-institutional program that is firmly anchored in the department of internal medicine.

Topics: aging, geriatrics, internal medicine, elderly
  

The author argues the case for departments of geriatric medicine as institutional structures that can advance research, improve teaching, and enhance patient care.

Topics: geriatrics, elderly
  

Prasad and colleagues' study in this issue points to an important, often overlooked issue in randomized, double-blind, placebo-controlled trials: testing the participants' assessment of whether they are receiving placebo or active drug.

Topics: common cold, zinc
  

In this issue, Arioglu and colleagues report that troglitazone led to better metabolic control and increased body fat in patients with lipoatrophic diabetes. What are the mechanisms of the efficacy of troglitazone in these patients?

Topics: insulin resistance, lipodystrophy
  
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David P. Hickey, FRCSI
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Leila Richards, MD, MPH
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Soheir A. Morsy, PhD
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Anthony F. Kirkpatrick, MD, PhD
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Richard Garfield, RN, DrPH
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Natalia Ganson-Myshkin, MD
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Jame Abraham, MD; Tito Fojo, MD, PhD; and Bradford J. Wood, MD
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John F. Burnum, MD
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Arthur E. Pitchenik, MD; Mark O'Connell, MD; and Donna Wiener, MD
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Joseph Carl Yarze, MD; Michael P. Chase, MD; and Kevin J. Herlihy, MD
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Topics: guidelines, clinical practice guideline
  
Deborah Gesensway
Topics: vitamin d
  
MRI
Anna B. Reisman, MD
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Edward V. Spudis, MD
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Topics: common cold, zinc acetate
  
Topics: coronary artery bypass surgery
  
Topics: lipodystrophy, troglitazone
  
Topics: platelet count measurement, rituximab, graft-versus-host disease, chronic
  
Topics: hiv, anti-hiv agents, seminal fluid
  
Nicholas J. Lekas, MD
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John G. Bartlett, MD

Topics covered in this Update include antimicrobial resistance, community-acquired pneumonia, and HIV infection.

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