0

Want to Subscribe?

Learn more about subscription options

Basic View  |  Expanded View
Sophie Grabar, MD, MPH; Vincent Le Moing, MD, MPH; Cécile Goujard, MD; Catherine Leport, MD, PhD; Michel D. Kazatchkine, MD, PhD; Dominique Costagliola, PhD; and Laurence Weiss, MD, PhD

Immunologic response after 6 months of highly active antiretroviral therapy indicates a favorable clinical outcome in HIV-infected patients regardless of virologic response. This finding suggests that both immunologic and virologic markers should be used in clinical practice to evaluate treatment response.

Topics: acquired immunodeficiency syndrome, antiretroviral therapy, highly active, treatment outcome, immunology, hiv-1 infection, ...
  
Morten Grønbæk, MD, DrMedSci; Ulrik Becker, MD, DrMedSci; Ditte Johansen, MSc; Adam Gottschau, MSc, PhD; Peter Schnohr, MD; Hans Ole Hein, MD; Gorm Jensen, MD, DrMedSci; and Thorkild I.A. Sørensen, MD, DrMedSci

This study suggests that wine intake may have a beneficial effect on all-cause mortality that is additive to the effect of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer.

Topics: ethanol, cancer, alcohol drinking, wine, mortality, coronary heart disease, beer
  
Clare Stevinson, BSc, MSc; Max H. Pittler, MD; and Edzard Ernst, MD, PhD, FRCP(Edin)

The available data suggest that garlic is superior to placebo in reducing total cholesterol levels. However, the size of the effect is modest, and its robustness is debatable. The use of garlic for hypercholesterolemia is therefore of questionable value.

Topics: hypercholesterolemia, garlic, total cholesterol
  
Roy Colven, MD; Robert D. Harrington, MD; David H. Spach, MD; Calvin J. Cohen, MD; and Thomas M. Hooton, MD

A retroviral rebound syndrome similar to that seen in primary HIV syndrome can occur in patients with chronic HIV infection after cessation of suppressive antiretroviral therapy.

Topics: retroviridae, hiv, chronic infection with, blood hiv rna, anti-retroviral agents, cd4 count ...
  
J. Michael Kilby, MD; Paul A. Goepfert, MD; Andrew P. Miller, MD; John W. Gnann Jr., MD; Michael Sillers, MD; Michael S. Saag, MD; and R. Pat Bucy, MD, PhD

Interruption of therapy may be associated with profound viral rebound and recurrence of the acute HIV syndrome.

Topics: hiv infection syndrome, acute, hiv, chronic infection with, anti-retroviral agents, interruption, viral ...
  
Joseph A. DeSimone, MD; Roger J. Pomerantz, MD; and Timothy J. Babinchak, MD

Clinicians caring for HIV-1–infected patients who are receiving highly active antiretroviral therapy must be aware of inflammatory reactions involving opportunistic infections, AIDS-associated malignant conditions, and infectious diseases.

Topics: antiretroviral therapy, highly active, hiv-1
  

Grabar and colleagues' study in this issue points to the importance of assessing the virologic and immunologic responses to treatment in the context of the underlying pathogenetic process. By doing so, we will be able to reach the ultimate goal of antiretroviral therapy: to prevent illness and prolong survival among HIV-infected patients.

Topics: anti-retroviral agents
  

In this issue, Temple and Ellenberg address the ethical challenge presented by use of placebo controls. Under what circumstances are placebo controls ethical, and what alternatives are available?

Topics: ethics
  
Jack Coulehan, MD, MPH

To many health professionals, the ideal patient just lies there quietly and cooperatively, watching television between occasional bouts of meaningful interaction with his family. Bob didn't measure up to this standard.

Topics: #
  

The Under Toad in John Irving's novel The World According to Garp is a grim symbol of the uncertainty of recurrence that patients with cancer face.

Topics: #
  
Topics: #
  
Sanjay Srivatsa, MD, MRCP; and Hamid R. Amjadi, DO
Topics: #
  
Andrew D. Auerbach, MD, MPH; Russell S. Phillips, MD; and Mary Beth Hamel, MD, MPH
Topics: #
  
Raphael B. Stricker, MD; and Billi Goldberg, MPA
Topics: #
  
Ann Danoff, MD; and Wai Lam W. Ling, PhD
Topics: #
  
John R. Mayo, MD; Elisabeth M. Baile, MSc; and Peter D. Pare, MD
Topics: #
  
Suman W. Rathbun, MD; Gary E. Raskob, PhD; and Thomas L. Whitsett, MD
Topics: #
  
Shakaib U. Rehman, MD; Ambreen Shakaib, MB; and Shaukat Rashid, MD
Topics: #
  
Topics: #
  
Randolph P. Cole, MD; W. Daniel Roberts, MS; and Matthew D. Cheng, MD
Topics: #
  
Topics: #
  
Topics: aids vaccines, vaccines
  
Topics: ethics
  
Topics: antiretroviral therapy, highly active, cell count, viral load result, treatment outcome, hiv ...
  
Topics: alcoholic beverages
  
Topics: hypercholesterolemia, garlic
  
Topics: hiv
  
Topics: hiv
  
Topics: #
  
Topics: #
  
Harvey Rubin, MD, PhD
Topics: #
  
Topics: #
  
Kim A. Eagle, MD

Among the topics covered in this Update are the prevention of coronary artery disease, use of antithrombins, and treatment of congestive heart failure.

Topics: #
  

Part one of this two-part article considers the ethical concerns about the use of placebo controls and describes the limited ability of active-control equivalence trials to establish efficacy of new therapies in many medical contexts.

Topics: ethics
  

Part two of this two-part article discusses more fully the ethical considerations for using placebo controls in particular settings. The value and relevance of placebo-controlled trials of new agents in situations in which proven effective therapy is available are also explored.

Topics: ethics, united states food and drug administration, toxic effect, biological products, antidepressive ...
  
Advertisement

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)