0
Basic View  |  Expanded View
Judith S. Currier, MD, MSc; Paige L. Williams, PhD; Susan L. Koletar, MD; Susan E. Cohn, MD, MPH; Robert L. Murphy, MD; Alison E. Heald, MD; Richard Hafner, MD; Ehab L. Bassily, MSc; Howard M. Lederman, MD, PhD; Charles Knirsch, MD, MPH; Constance A. Benson, MD; Hernan Valdez, MD; Judith A. Aberg, MD; and J. Allen McCutchan, MD

Prophylaxis against Mycobacterium avium complex infection can safely be withdrawn or withheld in adults with HIV infection whose CD4+ cell count increases during antiretroviral therapy.

Topics: acquired immunodeficiency syndrome, azithromycin, cd4 count determination procedure, cell count, mycobacterium avium ...
  
Patrick J. Stiff, MD; Judith Veum-Stone, MS; Hillard M. Lazarus, MD; Lois Ayash, MD; John R. Edwards, MD; Armand Keating, MD; John P. Klein, PhD; David J. Oblon, MD; Thomas C. Shea, MD; Stephan Thomé, MD; and Mary M. Horowitz, MD, MS

Some patients with ovarian cancer seem to have good outcomes after autotransplantation, although several biases may have affected these observations. Phase III trials are needed to compare outcomes after autotransplantation with outcomes after conventional chemotherapy.

Topics: chemotherapy regimen, transplantation, ovarian cancer, hematopoietic stem cells, platinum, transplantation, autologous
  
Andrea Z. LaCroix, PhD; Susan M. Ott, MD; Laura Ichikawa, MS; Delia Scholes, PhD; and William E. Barlow, PhD

In healthy older adults, low-dose hydrochlorothiazide preserves bone mineral density at the hip and spine. If the modest effects observed over 3 years are accumulated over 10 to 20 years, they may explain the one-third reduction in risk for hip fracture associated with thiazide in many epidemiologic studies.

Topics: bone mineral density, hydrochlorothiazide (hctz), elderly
  
Ezekiel J. Emanuel, MD, PhD; Diane Fairclough, DPH; Brian C. Clarridge, PhD; Diane Blum, MSW; Eduardo Bruera, MD; W. Charles Penley, MD; Lowell E. Schnipper, MD; and Robert J. Mayer, MD

Requests for euthanasia and physician-assisted suicide are likely to decrease as training in end-of-life care improves and the ability of physicians to provide this care to their patients is enhanced.

Topics: euthanasia, attitude, physician-assisted suicide
  
Mathew S. Maurer, MD; Wahida Karmally, MS, RD, CDE; Harold Rivadeneira, BS; Michael K. Parides, PhD; and Daniel M. Bloomfield, MD

Meal ingestion and head-up tilt-table testing are associated with increasing occurrences of symptomatic hypotension; 22% of functionally independent elderly persons in this study had symptomatic hypotension after eating a meal and undergoing tilt-table testing.

Topics: hypotension, postprandial period, posture, elderly, ingestion
  
Toru Suzuki, MD; Hirohisa Katoh, PhD; Yasuhiro Tsuchio, MD; Akira Hasegawa, MD; Masahiko Kurabayashi, MD; Atsushi Ohira, MD; Katsuhiko Hiramori, MD; Yasunari Sakomura, MD; Hiroshi Kasanuki, MD; Shingo Hori, MD; Naoki Aikawa, MD; Satoshi Abe, MD; Chuwa Tei, MD; Yoshihisa Nakagawa, MD; Masakiyo Nobuyoshi, MD; Kazuhiko Misu, MD; Tetsuya Sumiyoshi, MD; and Ryozo Nagai, MD

Levels of smooth-muscle myosin heavy-chain protein can be used to diagnose aortic dissection soon after symptom onset. This assay had the greatest diagnostic value in patients with proximal lesions.

Topics: dissection of aorta, muscle, smooth, myosin, myosin heavy chains
  

The robust findings of trials examining lipid-lowering drug therapy do not necessarily justify targeting low-density lipoprotein cholesterol to its lowest possible level, and the argument expressed by the phrase “the lower the better” is clearly not evidence based.

Topics: coronary arteriosclerosis, ldl cholesterol lipoproteins, hypercholesterolemia, clinical practice guideline, statins, lipids
  

In this issue, Stiff and colleagues report on the use of autologous stem-cell transplantation in patients with ovarian cancer. To determine the role of this therapy, the available data must be compared with data from other treatment strategies in similar patients. This editorial compares “best-case scenario” data on several approaches.

Topics: stem cells, hematopoietic stem cells, transplantation, ovarian cancer
  
Dean Gianakos, MD

The sign on the front door reads: Practitioner of the Alternative, Healing Arts. Rugs, curtains, and a fireplace in the corner warmed me. A friendly nurse escorted me to an examination room.

Topics: #
  
Topics: #
  
Topics: #
  
Daniel P. Sulmasy, OFM, MD, PhD; Wayne A. Ury, MD; Judith C. Ahronheim, MD; Mark Siegler, MD; Leon Kass, MD, PhD; John Lantos, MD; Robert A. Burt, JD; Kathleen Foley, MD; Richard Payne, MD; Carlos Gomez, MD; Thomas J. Krizek, MD; Edmund D. Pellegrino, MD; and Russell K. Portenoy, MD
Topics: #
  
Timothy E. Quill, MD; and Ira R. Byock, MD
Topics: #
  
Daniel P. Sulmasy, OFM, MD, PhD; Wayne A. Ury, MD; Judith C. Ahronheim, MD; Mark Siegler, MD; Leon Kass, MD, PhD; John Lantos, MD; Robert A. Burt, JD; Kathleen Foley, MD; Richard Payne, MD; Carlos Gomez, MD; Thomas J. Krizek, MD; Edmund D. Pellegrino, MD; and Russell K. Portenoy, MD
Topics: #
  
Timothy E. Quill, MD; Barbara Coombs Lee, PA, FNP, JD; and Sally Nunn, RN
Topics: #
  
Topics: #
  
Lois Snyder, JD; and Arthur L. Caplan, PhD
Topics: #
  
Daniel P. Sulmasy, OFM, MD, PhD; Wayne A. Ury, MD; Judith C. Ahronheim, MD; Mark Siegler, MD; Leon Kass, MD, PhD; John Lantos, MD; Robert A. Burt, JD; Kathleen Foley, MD; Richard Payne, MD; Carlos Gomez, MD; Thomas J. Krizek, MD; Edmund D. Pellegrino, MD; and Russell K. Portenoy, MD
Topics: #
  
Topics: #
  
Topics: #
  

Augusto and Michaela Odone (Nick Nolte and Susan Sarandon) resolve to learn all they can about their son's illness. Lorenzo's Oil provides a case worth examining not only for its own story but also for what it reveals about a movie's ability to work on many levels at once and thereby transcend its own particularities to illuminate wider aspects of medical and cultural realities.

Topics: #
  
Topics: #
  
Topics: #
  
George Young, MD
Topics: #
  
Topics: antibiotics, anti-hiv agents, mycobacterium avium-intracellulare infection, hiv infection
  
Topics: chemotherapy regimen, stem cells, hematopoietic stem cells, transplantation, ovarian cancer
  
Topics: diuretics, bone mineral density, elderly
  
Topics: euthanasia, cancer, attitude, physician-assisted suicide
  
Topics: blood pressure, postprandial period, elderly
  
Topics: dissection of aorta
  
Topics: #
  
Norton J. Greenberger, MD

This Update addresses several of the ongoing debates in the gastroenterology literature. Topics discussed include esophageal disorders, acid peptic disorders, gastrointestinal effects of cyclooxygenase-2 inhibitors, and hepatobiliary disease.

Topics: #
  
Advertisement
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)