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Amnon Sonnenberg, MD, MSc; Fabiola Delcò, MD, MPH; and John M. Inadomi, MD

Colonoscopy is a cost-effective means of screening for colorectal cancer because it reduces mortality at relatively low incremental costs. Low compliance rates render colonoscopy every 10 years the most cost-effective primary screening strategy for colorectal cancer.

Topics: colonoscopy, fecal occult blood test, cost-effectiveness analysis, colorectal cancer screening, colorectal cancer, ...
  
Sara-Joan Pinto-Sietsma, MD; Jaap Mulder; Wilbert M.T. Janssen, MD, PhD; Hans L. Hillege, MD; Dick de Zeeuw, MD, PhD; and Paul E. de Jong, MD, PhD

Smoking was found to be associated with albuminuria and abnormal renal function. However, these associations are less pronounced or absent in former smokers.

Topics: proteinuria, smoking, renal function, microalbuminuria
  
Shruti H. Mehta, MPH; Frederick L. Brancati, MD, MHS; Mark S. Sulkowski, MD; Steffanie A. Strathdee, PhD; Moyses Szklo, MD, DrPH; and David L. Thomas, MD, MPH

According to this national survey, type 2 diabetes occurs more often in persons with hepatitis C virus infection who are older than 40 years of age.

Topics: diabetes mellitus, type 2, infection, hepatitis c virus, hepatitis c, diabetes mellitus ...
  
Virginia D. Steen, MD; and Thomas A. Medsger Jr., MD

Renal crisis in patients with scleroderma can be effectively managed when hypertension is aggressively controlled with angiotensin-converting enzyme inhibitors. Patients should continue taking these drugs after beginning dialysis.

Topics: hemodialysis, scleroderma renal crisis, kidney, dialysis procedure
  
Jimmy Dy Chua, MD; Bruce L. Wilkoff, MD; Irene Lee, MD; Nour Juratli, MD; David L. Longworth, MD; and Steven M. Gordon, MD

For infections related to implantable electrophysiologic devices, complete device removal and antimicrobial therapy allow timely, successful reimplantation at a remote anatomic site without substantial risk for surgical mortality or recurrent infection.

Topics: infection, heart
  
Donald P. Kotler, MD

Recent advances in the understanding of selected aspects of cachexia are discussed. Among these are changes in body composition, food intake, intermediary metabolism, energy balance, cytokine regulation, and recent therapeutic initiatives.

Topics: cachexia
  
Conference Chair: David T. Felson, MD, MPH; Conference Organizer: Reva C. Lawrence, MPH; Discussants: Paul A. Dieppe, MD; Rosemarie Hirsch, MD, MPH; Charles G. Helmick, MD; Joanne M. Jordan, MD, MPH; Raynard S. Kington, MD, PhD; Nancy E. Lane, MD; Michael C. Nevitt, PhD; Yuqing Zhang, DSc; MaryFran Sowers, PhD; Timothy McAlindon, MD, MPH; Tim D. Spector, MD, MSc; A. Robin Poole, PhD, DSc; Susan Z. Yanovski, MD; Gerard Ateshian, PhD; Leena Sharma, MD; Joseph A. Buckwalter, MD; Kenneth D. Brandt, MD; and James F. Fries, MD

Part 1 of this two-part conference addresses a new understanding of what osteoarthritis is and the risk factors that predispose to disease occurrence.

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This paper briefly reviews existing clinical trials registries, discusses challenges in building registries, and reviews some of the benefits of registries.

Topics: access to information
  

It now appears almost certain that screening colonoscopy can effectively reduce colorectal cancer–related mortality and is probably more effective than fecal occult blood testing, flexible sigmoidoscopy, or both. An important remaining question is how much this strategy will cost. In this issue, Sonnenberg and colleagues attempt to answer that question.

Topics: colorectal cancer, colonoscopy
  

The association between chronic hepatitis C virus infection and type 2 diabetes mellitus, reported by Mehta and colleagues in this issue, seems genuine. However, numerous questions must still be addressed, most notably those regarding the nature of the link between the disorders.

Topics: diabetes mellitus, type 2, infection, hepatitis c virus
  
Lori A. Borella, MD

During a rural medicine clerkship, a medical student encounters a surprising link to her past.

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Dick de Waard, PhD; and Karel A. Brookhuis, PhD
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Thomas H. Lee, MD; Jessica Dudley, MD; and Harold J. Demonaco, MS
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James T. Angello, PharmD; and Howard M. Druce, MD
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John M. Weiler, MD; George Woodworth, PhD; and Ginger Watson, PhD
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Ravi Sudhir Ravinuthala, MD, MRCP; and Uday Nori, MD
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Ichiro Yoshikawa, MD; Ikuo Murata, MD; and Makoto Otsuki, MD
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Aaron Levin
Topics: vaccines
  
George Young, MD
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Zijad Duraković, MD
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Zijad Duraković, MD
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Topics: colorectal cancer
  
Topics: smoking, diabetes mellitus, renal function, diabetes mellitus, type 2
  
Topics: diabetes mellitus, infection, hepatitis c virus
  
Topics: scleroderma renal crisis
  
Topics: infection, heart
  
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Lynn M. Schuchter, MD; and Daniel G. Haller, MD

Among the many important papers in the field of oncology published in 1999, this Update focuses on studies of breast cancer, cervical cancer, multiple myeloma, colorectal cancer, and prostate cancer.

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