This study examined the clinical course of 168 patients with mild to moderate idiopathic pulmonary fibrosis. Physiologic variables changed minimally, but 21% of patients died. Acute clinical deterioration preceded death in 47% of decedents. Acute deterioration in mild to moderate disease is an ominous sign of the need for referral for lung transplantation.
Ann Intern Med. 2005;142(12_Part_1):963-967. doi:10.7326/0003-4819-142-12 Part 1-200506210-00005