The authors randomly assigned 40 older adults with symptomatic peripheral arterial disease to ramipril, 10 mg/d, or to placebo. After adjustment for between-group baseline differences, mean pain-free walking time after ramipril treatment was 227 seconds (95% CI, 175 seconds to 278 seconds; P < 0.001) longer than after placebo treatment. Similarly, maximum walking time improved by 451 seconds in the ramipril group (CI, 367 seconds to 536 seconds; P < 0.001) but did not change in the placebo group. No adverse events were reported.
Ann Intern Med. 2006;144(9):660-664. doi:10.7326/0003-4819-144-9-200605020-00009