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The U.S. Preventive Services Task Force (USPSTF) updates its recommendation statement on screening for colorectal cancer. Screening using fecal occult blood testing (FOBT), sigmoidoscopy, or colonoscopy is recommended in adults beginning at age 50 years and continuing until age 75 years (A recommendation). The USPSTF recommends against routine screening in adults 76 to 85 years of age, but certain considerations may support screening in an individual patient (C recommendation). It recommends against screening in adults older than age 85 years (D recommendation). Evidence is insufficient to assess the benefits and harms of computed tomographic colonography and fecal DNA testing as screening modalities for colorectal cancer (I statement).