E. M. GOLD, M.D.; J. R. KENT, M.D.; P. H. FORSHAM, M.D.
Disorders involving the adrenocortical secretion of cortisol have become more precisely characterized within recent years as knowledge concerning pituitary-adrenal physiology has increased and as newer, more critical means of study have become available. The secretion of cortisol by the adrenal cortex is normally regulated by corticotropin discharged from the anterior pituitary gland in response to stimuli from the ventral hypothalamus.1 A quantitative estimate of the adrenal component of this system became possible when various procedures employing corticotropin as a direct and specific stimulator of the adrenal cortices were developed.2, 3 For qualitatively demonstrating the extent of adrenocortical regulation by corticotropin,
GOLD EM, KENT JR, FORSHAM PH. CLINICAL USE OF A NEW DIAGNOSTIC AGENT, METHOPYRAPONE (SU-4885), IN PITUITARY AND ADRENOCORTICAL DISORDERS12. Ann Intern Med. 1961;54:175–188. doi: 10.7326/0003-4819-54-2-175
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Published: Ann Intern Med. 1961;54(2):175-188.
Adrenal Disorders, Endocrine and Metabolism, Neurology, Pituitary Disorders.
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