WILLIAM FRANKLIN, M.D.; FRANCIS C. LOWELL, M.D., F.A.C.P.
An association between cigarette smoking and chronic obstructive pulmonary disease in patients has been shown by several writers.1-4 Furthermore, it has been postulated that in such patients, smoking is the cause of the obstructive process. This may be due to inflammatory changes in the lining of the airway that lead to narrowing of the lumen or to distortion of the airway so that the flow of air is impeded.
If smoking is a cause of obstructive pulmonary disease, one would expect to find it in some degree among many who smoke but who do not have manifest disease, provided
FRANKLIN W, LOWELL FC. UNRECOGNIZED AIRWAY OBSTRUCTION ASSOCIATED WITH SMOKING: A PROBABLE FORERUNNER OF OBSTRUCTIVE PULMONARY EMPHYSEMA12. Ann Intern Med. 1961;54:379–386. doi: 10.7326/0003-4819-54-3-379
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Published: Ann Intern Med. 1961;54(3):379-386.
Cardiology, Chronic Obstructive Airway Disease, Coronary Risk Factors, Pulmonary/Critical Care, Smoking.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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