NORMAN M. KAPLAN, M.D.; ROBERT G. NORFLEET
Significant advances have recently been made in our understanding of sexual differentiation and maturation. Reports on the application of this knowledge to the differential diagnosis of hypogonadism in the male have been essentially limited to the study of patients who presented themselves for examination because of infertility. In this paper we present an evaluation of a large number of young men with sexual underdevelopment manifested by eunuchoidism, gynecomastia, or small testes. An attempt has been made to establish the incidence of such aberrations and to analyze intensively their nature. Of particular significance has been the discovery of Klinefelter's syndrome in
KAPLAN NM, NORFLEET RG. HYPOGONADISM IN YOUNG MEN (WITH EMPHASIS ON KLINEFELTER'S SYNDROME)*†. Ann Intern Med. 1961;54:461–481. doi: https://doi.org/10.7326/0003-4819-54-3-461
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Published: Ann Intern Med. 1961;54(3):461-481.
Endocrine and Metabolism, Hospital Medicine.
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