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Since Rusticiano suggested, in 1298, that the difficulties Marco Polo experienced in the mountains of Tibet were related to noxious effects of high altitude, man has been interested in "altitude medicine." In the last century, stimulated by desires of mountaineers to climb the peaks of the world's highest mountains as well as by new fields of aviation and space travel, scientists have been studying problems related to high altitude. Physicians and physiologists who have accompanied expeditions into the high Himalayan mountains have reported their observations of the climbers at various altitudes.
Between 1950 and 1955 several expeditions to the Himalayan
Expeditions Francaises a l'Himalaya: Aspect Medical.. Ann Intern Med. 1961;54:593–594. doi: https://doi.org/10.7326/0003-4819-54-3-593_2
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Published: Ann Intern Med. 1961;54(3):593-594.
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