RICHARD M. HAYS, M.D.; ALEXANDER LEAF, M.D.
In recent years, there has been considerable progress in our understanding of the role of antidiuretic hormone in the renal concentrating mechanism. Studies by Hargitay and Kuhn,1 Wirz,2 Gottschalk,3 and others4-6 have led to our present picture of the mammalian nephron as an efficient countercurrent system. A concentrated urine is formed when antidiuretic hormone alters the permeability of renal tubular cells, permitting the tubular urine to come rapidly into osmotic equilibrium with the hypertonic interstitial fluid of the renal medulla.
Under certain conditions, however, an apparent resistance to the action of antidiuretic hormone may develop. Despite the administration of large
HAYS RM, LEAF A. THE PROBLEM OF CLINICAL VASOPRESSIN RESISTANCE: IN VITRO STUDIES*†. Ann Intern Med. 1961;54:700–709. doi: https://doi.org/10.7326/0003-4819-54-4-700
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Published: Ann Intern Med. 1961;54(4):700-709.
Hospital Medicine, Nephrology, Urological Disorders.
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