ISRAELI A. JAFFE, M.D.
In 1907 Whipple described a disease in a 36-year-old physician which was characterized by steatorrhea, weakness, loss of weight, anemia, polyarthritis, and cough.1 At post-mortem the most striking finding was a massive deposition of fat in the intestinal and mesenteric lymphatic tissues. Whipple named this disease "intestinal lipodystrophy." At this writing, 87 cases have been reported in the world literature, 69 of which fulfill all of the pathologic criteria. In a recent review, Farnan tabulated the salient clinical features in 60 well documented cases, and added seven more from Great Britain.2 He found that diarrhea, arthritis, and abdominal pain were
JAFFE IA. WHIPPLE'S INTESTINAL LIPODYSTROPHY1. Ann Intern Med. 1961;54:776–790. doi: 10.7326/0003-4819-54-4-776
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Published: Ann Intern Med. 1961;54(4):776-790.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Infectious Disease.
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