JOHN M. THAYER, M.D., F.A.C.P.; WILLIAM J. GLECKLER, M.D., F.A.C.P.; ROBERT O. HOLMES, M.D.
Edema and other signs of fluid retention may occasionally increase rather than regress during the course of treatment of congestive heart failure with mercurial diuretics. This lack of response to treatment may be related to the severe nature of the cardiac lesion. Recently, however, Burack et al.1 have described four cases of congestive failure which they felt led to the development of the nephrotic syndrome, characterized by heavy proteinuria, hypercholesterolemia, hypoalbuminemia, and edema. While many cardiologists and students of nephrosis find no causal relationship between the two disorders,2-13 the case presented here suggested such an association and prompted a review
THAYER JM, GLECKLER WJ, HOLMES RO. THE DEVELOPMENT OF THE NEPHROTIC SYNDROME DURING THE COURSE OF CONGESTIVE HEART FAILURE: CASE REPORT AND REVIEW OF THE LITERATURE*. Ann Intern Med. 1961;54:1013–1025. doi: https://doi.org/10.7326/0003-4819-54-5-1013
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Published: Ann Intern Med. 1961;54(5):1013-1025.
Cardiology, Heart Failure, Nephrology, Nephrotic Syndrome.
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