H. L. Conn Jr., M.D., F.A.C.P.; R. J. Luchi, M.D.; T. H. Helwig Jr., M.D.
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Despite wide recognition of the electromechanical cardiac depressant and vasodilating effects of quinidine, the basic mechanisms responsible are obscure. Equally obscure are the mechanisms responsible by which the commonly used therapeutic agents reverse these effects. Even the usefulness of some recommended therapeutic agents is in doubt. Our data and those of others, derived from perfused heart experiments, have indicated that cardiac depression may in great part be due to derangement in cation movements and distribution. Subsequent in vitro dialysis studies of quinidine-protein binding led us to suggest that there is a specific binding at the cell surface between quinidine, cell
Conn HL, Luchi RJ, Helwig TH. Mechanisms of Quinidine Action on the Circulation and Therapeutic Reversal of Toxic Effects.. Ann Intern Med. 1961;54:1032–1033. doi: https://doi.org/10.7326/0003-4819-54-5-1032_2
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Published: Ann Intern Med. 1961;54(5):1032-1033.
Cardiology, Emergency Medicine, Rhythm Disorders and Devices.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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