J. A. Spittel Jr., M.D., (Assoc.); C. A. Pascuzzi, M.D.; J. H. Thompson Jr., M.D.; C. A. Owen Jr., M.D.
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Some patients with arteriosclerosis obliterans experience a chronic course; others have acute arterial occlusion. Previous investigators have suspected hypercoagulability of the blood as the cause of the acute thrombotic arterial occlusion, but methods consistently effective in demonstrating hypercoagulability have not emerged.
During normal blood coagulation, the generation of thromboplastin requires more time than all other phases of clotting combined. Accordingly, the thromboplastin generation test (TGT), designed to measure the rate of formation of thromboplastin and the amount formed under standardized conditions, was utilized in this study of patients with arteriosclerosis obliterans. To increase the likelihood of detecting any acceleration of
Spittel JA, Pascuzzi CA, Thompson JH, et al. Accelerated Thromboplastin Generation in Patients with Acute Peripheral Arterial Occlusion Complicating Arteriosclerosis Obliterans.. Ann Intern Med. 1961;54:1040. doi: https://doi.org/10.7326/0003-4819-54-5-1040_2
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Published: Ann Intern Med. 1961;54(5):1040.
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