S. Brunjes, M.D.; J. E. Hodgman, M.D.; J. Nowack, M.D.; V. J. Johns Jr., M.D., F.A.C.P.
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Although the adrenal medulla is not an essential organ, it is well known that it plays a role in the regulation of blood sugar through the effect of epinephrine on glycogenolysis. At the present time, adrenal medullary insufficiency is just emerging as a recognized syndrome.
In 1959, Broberger, Jungner, and Zetterstrom reported several children with "idiopathic spontaneous hypoglycemia of infancy" (McQuarrie's syndrome) whose epinephrine secretion failed to increase after insulin-induced hypoglycemia. They postulated that the cause of the spontaneous fasting hypoglycemia was a failure of the adrenal medulla to increase secretion of epinephrine during hypoglycemia.
We have studied six infants
Brunjes S, Hodgman JE, Nowack J, Johns VJ. An Adrenal Medullary Function Test.. Ann Intern Med. 1961;54:1043. doi: 10.7326/0003-4819-54-5-1043_2
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Published: Ann Intern Med. 1961;54(5):1043.
Adrenal Disorders, Endocrine and Metabolism.
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