I. H. Krakoff, M.D., F.A.C.P.; M. E. Balis, Ph.D.; D. A. Karnofsky, M.D.
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2-ethylamino-1,3,4-thiadiazole (TDA) and related 2-substituted thiadiazoles have been found to produce a parallel increase in blood and urinary uric acid in man. Studies of the incorporation into uric acid of isotopically labeled purines and purine precursors have shown that this "uricogenic" effect is the result of an increase in de novo biosynthesis of uric acid.
The increase in uric acid synthesis and the characteristic glossitis produced by TDA were blocked by nicotinamide or nicotinic acid and by the nicotinamide precursor, tryptophan. The uricogenic effect, but not the glossitis, was prevented by azaserine (O-diazo-acetyl-L-serine), DON (6-diazo-5-oxo-L-norleucine), and 6-mercaptopurine, compounds which are
Krakoff IH, Balis ME, Karnofsky DA. Relation of 2-substituted Thiadiazoles to Purine and Nicotinamide Metabolism.. Ann Intern Med. ;54:1045–1046. doi: 10.7326/0003-4819-54-5-1045_3
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Published: Ann Intern Med. 1961;54(5):1045-1046.
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