I. Pastan, M.D.; J. B. Field, M.D.
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Although TSH has been shown to increase thyroid growth, respiration, iodine, and phospholipid metabolism, its mechanism of action is unknown. We noted that the oxidation of glucose-1-C14 and glucose-6-C14 to C14O2 by thyroid slices in vitro was stimulated five minutes after the addition of TSH. This early effect suggested that TSH acts directly on glucose oxidation or a closely related metabolic step, and that previously noted effects of TSH were secondary. This stimulation of glucose oxidation was specific since: (1) TSH had no effect on the glucose oxidation of many other tissues; (2) none of the other anterior pituitary hormones
Pastan I, Field JB. Stimulation of Glucose Oxidation in Thyroid by Thyroid Stimulating Hormone (TSH) and Other Substances.. Ann Intern Med. 1961;54:1046–1047. doi: https://doi.org/10.7326/0003-4819-54-5-1046_3
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Published: Ann Intern Med. 1961;54(5):1046-1047.
Endocrine and Metabolism, Thyroid Disorders.
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