B. Alexander, M.D.; L. Pechet, M.D.; A. Kliman, M.D.
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Now that infectious nutritional neonatal and other diseases are controllable, thromboembolic disease has become a major threat to life and limb. Expanding knowledge of the blood fibrinolytic system and its potential therapeutic use have stimulated renewed interest in blood proteases, particularly in relation to coagulation. Additional significance derives from their possible etiologic importance in atherosclerosis, according to the Rokitansky-Duguid-Astrup concept of imbalance between arterial wall fibrin deposition and failure of its removal.
Our investigations to be presented demonstrate:
1. A combination of in vivo coagulation experimentally induced by the generalized Shwartzman reaction, with streptokinase (SK) activated plasminogen (fibrinolysin), produces profound
Alexander B, Pechet L, Kliman A. Proteolysis, Fibrinolysis and Coagulation: Significance in Thrombolytic Therapy.. Ann Intern Med. 1961;54:1050–1051. doi: 10.7326/0003-4819-54-5-1050_3
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Published: Ann Intern Med. 1961;54(5):1050-1051.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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