A. J. Quick, M.D.
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The diagnostic triad—history, physical, and laboratory—is the key to the study of the hereditary bleeding diseases. From the history, it can usually be determined whether the bleeding is spontaneous (capillary) or traumatic (arteriolar). The prototype of the first is found in thrombocytopenia while the second is characteristic of hemophilia.
The three hereditary types and the hemorrhagic diseases belonging to them are: 1. sex-linked recessive- classical hemophilia and hemophilia B (also known as Christmas disease and PTC deficiency); 2. autosomal dominant-telangiectasia and von Willebrand's disease (pseudohemophilia); and 3. autosomal recessive- hypoprothrombinemia vera, afibrinogenemia, hyperheparinemia, and deficiencies of factors V (labile factor),
Quick AJ. The John Phillips Memorial Lecture: The Diagnosis of Common Hereditary Hemorrhagic Diseases.. Ann Intern Med. 1961;54:1052. doi: 10.7326/0003-4819-54-5-1052_2
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Published: Ann Intern Med. 1961;54(5):1052.
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