J. A. Colwell, M.D.; S. P. Tillman, M.D.
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With the development of effective antifungal chemotherapy, early and accurate diagnosis of disseminated coccidioidomycosis is imperative. In the present study, 50 cases of coccidioidomycosis were first observed shortly after the onset of the disease and were followed for up to three years. The clinical course in 42 patients with primary pulmonary coccidioidomycosis was compared with that of eight patients with disseminated coccidioidomycosis. It was found that certain characteristics clearly separated the two groups. Soon after the primary infection, dissemination (extrapulmonary spread) could be first suspected in those patients with a history of weight loss, prolonged duration of generalized symptoms (malaise,
Colwell JA, Tillman SP. Disseminated Coccidioidomycosis: Its Natural Course and Treatment.. Ann Intern Med. 1961;54:1054. doi: https://doi.org/10.7326/0003-4819-54-5-1054_1
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Published: Ann Intern Med. 1961;54(5):1054.
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