E. Witebsky, M.D.
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Sensitization to a patient's own tissue constituents has been implicated in the etiology of several diseases in recent years. However, the justification for such an assumption in each case demands critical analysis. Thyroglobulin has been found to be auto-antigenic. In our hands, rabbit thyroglobulin incorporated into Freund adjuvants and injected intradermally into normal rabbits produced circulating antibodies, as well as histologic changes in the thyroid gland of the immunized animal which resembled those of chronic thyroiditis in man. Also, thyroglobulin, when reinjected into the same rabbit, proved to be antigenic. The sera of patients suffering from chronic thyroiditis frequently were
Witebsky E. Autoimmunity.. Ann Intern Med. 1961;54:1058–1059. doi: https://doi.org/10.7326/0003-4819-54-5-1058_3
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Published: Ann Intern Med. 1961;54(5):1058-1059.
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