H. C. Sweet, M.D., F.A.C.P.; J. P. Wyatt, M.D.; A. J. Fritsch, M.D.; P. W. Kinsella, M.D.
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Two distinct types of pulmonary emphysema have been recognized by post-mortem examination of the lungs by macrosection technics. Seventy-five such cases (39 centrilobular, 36 panlobular) have been subjected to clinical analysis. Centrilobular emphysema is characterized by distention and destruction of the central part of secondary lung lobules involving the terminal respiratory bronchioles; panlobular (panacinar) by destruction of entire secondary lung lobules.
Clinically, three-fourths of centrilobular cases have an insidious onset with dyspnea preceded by cough. The patient is always underweight; blood pressure is normal or low; heart failure occurs in 50% and usually late in the disease. Roentgenographically, heart size
Sweet HC, Wyatt JP, Fritsch AJ, et al. Panlobular and Centrilobular Emphysema: Correlation of Clinical Findings with Pathologic Patterns.. Ann Intern Med. 1961;54:1060–1061. doi: 10.7326/0003-4819-54-5-1060_3
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Published: Ann Intern Med. 1961;54(5):1060-1061.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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