H. S. Bowman, M.D., F.A.C.P.; J. F. Mohn, M.D.; R. M. Lambert; F. W. Brason, M.D.
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In an earlier study of experimental transfusion of donor plasma containing blood group antibodies into incompatible normal human recipients, a single ACD plasma containing exceptional anti-CD antibodies induced iso-immune hemolytic anemia in a CwDe/Ce (R1wR1) volunteer. The hematologic and immunologic observations made closely paralleled those found in naturally-occurring warm-antibody type acquired hemolytic anemia, and indicated that further detailed studies on additional recipients transfused with this unique anti-CD plasma might provide some insight into the pathogenesis of the spontaneously-occurring disorder.
The equivalent of a single unit of plasma of a sterile pool of three bleedings from the same donor was transfused
Bowman HS, Mohn JF, Lambert RM, et al. Experimental Induction of Iso-Immune Hemolytic Anemia in Man by Transfusion of Unusually Potent Anti-Rh Antibodies.. Ann Intern Med. 1961;54:1061. doi: https://doi.org/10.7326/0003-4819-54-5-1061_1
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Published: Ann Intern Med. 1961;54(5):1061.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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