LEON J. MARKS, M.D.; ALBERT E. ANDERSON, M.D.; HARVEY LIBERMAN, M.D.
The role of pituitary corticotropin in the regulation of the adrenal secretion of cortisol during the basal state, as well as during periods of stress, has been well documented.1 The work of several investigators has suggested the existence of a pituitary factor which is separate from conventional ACTH and which primarily affects adrenal growth and weight maintenance without causing the secretion of adrenal hormones.2, 3 Although Jailer et al.4 have demonstrated the presence of an adrenal weight-maintaining substance in patients with Cushing's disease due to bilateral adrenal hyperplasia by assaying their plasma in hypophysectomized rats, the clinical significance of a
MARKS LJ, ANDERSON AE, LIBERMAN H. CARCINOMA OF THE LUNG ASSOCIATED WITH MARKED ADRENOCORTICAL HYPERPLASIA AND ADRENAL HYPER-RESPONSIVENESS TO ACTH IN THE ABSENCE OF CUSHING'S SYNDROME1. Ann Intern Med. 1961;54:1243–1248. doi: 10.7326/0003-4819-54-6-1243
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Published: Ann Intern Med. 1961;54(6):1243-1248.
Adrenal Disorders, Endocrine and Metabolism, Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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