WILLIAM E. ESCOVITZ, M.D.; IRVING M. REINGOLD, M.D.
For many years bronchial carcinoid, a type of bronchial adenoma, was considered not to be potentially malignant. In 1937, however, Zamora and Schuster1 mentioned the first case of metastasis from a bronchial adenoma. A correlation between malignant carcinoid tumors of the small intestine and a bizarre syndrome, subsequently called "carcinoid syndrome," was emphasized by Thorson et al.2 in 1954.
In 1956 MacDonald3 reviewed 57 cases of carcinoid syndrome with the primary tumor in the gastrointestinal tract. In the same year, Mattingly4 in a thorough review of the literature described the functioning carcinoid tumor. Through 1959 a total of at least
ESCOVITZ WE, REINGOLD IM. FUNCTIONING MALIGNANT BRONCHIAL CARCINOID WITH CUSHING'S SYNDROME AND RECURRENT SINUS ARREST*. Ann Intern Med. 1961;54:1248–1259. doi: https://doi.org/10.7326/0003-4819-54-6-1248
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Published: Ann Intern Med. 1961;54(6):1248-1259.
Adrenal Disorders, Cardiology, Endocrine and Metabolism, Rhythm Disorders and Devices.
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