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ACP Journal Club |19 August 2008

Risk for cancer was still increased over 2 years after stopping hormone therapy

Angela M. Cheung, MD, PhD

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Heiss G, Wallace R, Anderson GL, et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA. 2008;299:1036-45. 18319414

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After release of the initial results of the WHI trial, which showed that hormone therapy (HT) increased risks for CV and thromboembolic events and invasive breast cancer (1), many postmenopausal women discontinued HT. In 2003, Ravdin and colleagues (2) described a decline in breast cancer incidence coinciding with decreased HT prescriptions; however, Heiss and colleagues found that cancer risk increased after stopping HT. More diagnoses of breast cancer were made in...
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Cheung AM. Risk for cancer was still increased over 2 years after stopping hormone therapy. Ann Intern Med. 2008;149:JC2–11. doi: https://doi.org/10.7326/0003-4819-149-4-200808190-02011

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Published: Ann Intern Med. 2008;149(4):JC2-11.

DOI: 10.7326/0003-4819-149-4-200808190-02011

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