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ACP Journal Club |16 September 2008

Prasugrel reduced ischemic outcomes more than did clopidogrel in patients receiving stents for ACS

William B. Hillegass, MD, MPH; Brigitta C. Brott, MD

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Wiviott SD, Braunwald E, McCabe CH, et al. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet. 2008;371:1353-63. 18377975

Cardiology:

In ex vivo aggregation, prasugrel is a more rapid, consistent, and potent P2Y12 adenosine diphosphate platelet-receptor antagonist than clopidogrel (1). A 300-mg loading dose of clopidogrel requires ≥ 6 and up to 18 hours to achieve maximum clinical benefit (2). Even with an optimal 600-mg loading dose of clopidogrel,...
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Hillegass WB, Brott BC. Prasugrel reduced ischemic outcomes more than did clopidogrel in patients receiving stents for ACS. Ann Intern Med. 2008;149:JC3–12. doi: https://doi.org/10.7326/0003-4819-149-6-200809160-02012

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Published: Ann Intern Med. 2008;149(6):JC3-12.

DOI: 10.7326/0003-4819-149-6-200809160-02012

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